Drug-radiopharmaceutical interactions

  • Azuwuike Owunwanne
  • Mohan Patel
  • Samy Sadek


Radiopharmaceuticals are designed to have specific biodistribution and/or elimination patterns when administered to normal subjects. In the presence of biochemical and/or pathophysiologic changes, the normal biodis-tribution and elimination pattern may be altered. It is this altered biologic behavior that helps a physician make a diagnosis. Altered biologic behavior may also be due to interferences caused by pharmacodynamic effects of drug(s). Hence, drug-radiopharmaceutical in teraction will be defined as altered biologic behavior due to tissue response of administered drug. When the altered biologic behavior is desired, the alteration is used for diagnostic intervention or drug therapy monitoring; when it is undesired, it may be due to toxicity or direct interaction. Although there are various classifications for drug-radiopharmaceutical interactions, [1–3] the most practical approach is the one summarized in Figure 6.1.


Myocardial Perfusion Kawasaki Disease Biliary Atresia Bile Flow Renovascular Hypertension 


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Copyright information

© Azuwuike Owunwanne, Mohan Patel and Samy Sadek 1995

Authors and Affiliations

  • Azuwuike Owunwanne
    • 1
  • Mohan Patel
    • 2
  • Samy Sadek
    • 3
  1. 1.Department of Nuclear Medicine, Faculty of MedicineKuwait UniversityKuwait
  2. 2.Kuwait Central Radiopharmacy Kuwait Cancer Control CenterMinistry of Public HealthKuwait
  3. 3.Department of Nuclear Medicine Faculty of MedicineKuwait UniversityKuwait

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