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Biodegradable Drug Delivery Systems Based on Polypeptides

  • Robert V. Petersen

Abstract

A new dimension to the use of polymeric materials as drug delivery devices is the incorporation of biodegrability into the system. A number of degradable polymers are potentially useful for this purpose, including synthetic and natural substances. A number of such substances are described in this chapter. However, major emphasis is placed on synthetic poly(α-amino acids). These polymers are useful for matrix and reservoir-type delivery systems and, in addition, when difunctional amino acids, such as glutamic acid, are utilized, polymer/drug conjugates represent another new dimension. In polymer/drug conjugates, the drug is covalently bonded directly to the polymeric “backbone” or to a spacer group between the drug and polymer. The bond must be of a type which hydrolyzes more rapidly than the amide bonds in the polymeric backbone. A number of such conjugates have been synthesized and evaluated for in vitro and in vivo hydrolysis and for potential toxicity. It appears that this concept can be utilized to advantage in the development of delivery systems for a wide variety of bioactive substances.

Keywords

Drug Release Drug Delivery System Bioactive Agent Reactive Functional Group Affinity Label 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Robert V. Petersen
    • 1
  1. 1.Department of Pharmaceutics, College of PharmacyUniversity of UtahSalt Lake CityUSA

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