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Biological Activities of cis-Dichlorodiamineplatinum II and Its Derivatives

  • Charles E. CarraherJr.
  • William J. Scott
  • David J. Giron

Abstract

Malignant neoplasms are the second leading cause of death. In 1964 Rosenberg and co-workers discovered that cis-dichlorodiamineplatinum II prevented select bacteria from dividing. This led to the licensing, in 1980, of Platinol and brought about the synthesis and characterization of numerous derivatives of cis-dichlorodiamineplatinum II. The structural requirements, mode of activity, animal and human toxicity, and antineoplastic effects of such derivatives are reviewed. Due to the rapidity with which antineoplastic platinum compounds are filtered through the kidney, a high level of renal, and related, damage occurs. One method of lowering this toxicity, which may also permit prolonged controlled release of the active platinum-containing compounds, is the placement of the platinum into polymers.The rational synthesis and biological and physical characterization of these polymeric platinum-containing polymers is discussed.

Keywords

Trans Isomer Platinum Complex Platinum Compound Platinum Drug Polyamine Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations Used in Chapter

Å

Angstrom (10-8 cm)

ACD

Actinomycin D

BLM

Bleomycin

cDDP

cis-Dichlorodiamineplatinum II

cTCP

cis-Tetrachlorodiamineplatinum IV

CTX

Cyclophosphamide

DEIP

cis-Dichlorobis(2-aminoethanol)platinum II

DENP

cis-Dichloro(ethylenediamine)platinum II

Hz

Hertz, frequency

% ILS

Percentage increased life span

IR

Infrared spectroscopy

MCCP

Malonato(1,2-diaminocyclohexane)platinum II

MS

Mass spectroscopy

NMR

Nuclear magnetic resonance spectroscopy

Poly C

Polycytosine

Poly G—C

Coupled strands of polyguanine and polycytosine

TC

Treated-to-control tumor ratio

TG

Thermogravimetric analysis

TI

Therapeutic index

UV

Ultraviolet spectroscopy

VLB

Vinblastine

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Charles E. CarraherJr.
    • 1
  • William J. Scott
    • 1
  • David J. Giron
    • 1
  1. 1.Departments of Chemistry and Microbiology and ImmunologyWright State UniversityDaytonUSA

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