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Functionality and Applicability of Synthetic Nucleic Acid Analogues

  • Kiichi Takemoto

Abstract

Of the chemistry of synthetic nucleic acid analogues, some of the new aspects of their functionality and applicability were reviewed. The specific interaction was studied particularly on poly-L-lysine derivatives having nucleic acid bases in relation to their molecular weight, their conformation in solutions, and other properties. From a photodimerization study on the model compounds containing thymine bases, intramolecular features of the reaction were elucidated. Graft copolymers of the bases on polyethyleneimine were also considered. New results on the functionality of the supported nucleic acid bases as polymeric reagents were given. The preparation of relating cyclic derivatives of pyrimidine bases, as well as their applicability to the field of organic synthesis, were shown. Owing to the specific properties of the polymers, the studies will find a number of applications, including separation techniques and polymeric drug chemistry.

Keywords

Helical Conformation Nucleic Acid Basis Adenine Thymine Interferon Inducer Polymeric Reagent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Kiichi Takemoto
    • 1
  1. 1.Faculty of EngineeringOsaka UniversityYamadaoka, Suita, OsakaJapan

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