Influence of Centrally Administered Taurine on Thermoregulation and Fever
One of the most striking and consistent effects of central administration of taurine is hypothermia. First observed in rats in 1972 by Sgaragli and Pavan (22), this effect has since been found to occur in several other species (Table 1). The relatively consistent finding of hypothermia among various mammalian species given taurine centrally in thermoneutral and cold environments indicates that taurine has a rather uniform and compelling influence on temperature control of homeotherms. In characterizing the nature of the influence of a substance on body temperature one of the first steps is to administer it at different ambient temperatures (3). When this was done using rats (22) and rabbits (12, Fig. 1) taurine caused hypothermia in thermoneutral environments, greater hypothermia in the cold and had no significant effect on body temperature in the heat. Similar effects of taurine have recently been observed in young and aged squirrel monkeys (Clark and Lipton, unpublished). However, in these experiments there was a small decrease in body temperature when taurine was given in a 30°C environment. This difference in response from that of other species may reflect a higher thermoneutral zone in the squirrel monkey.
KeywordsBody Temperature Central Administration Hypo Taurine Prolonged Fever Febrile Response
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