Advertisement

Central Neuropharmacology of D-Ala2-Met-Enkephalinamide and its Interactions with Taurine in Rats

  • Kanji Izumi
  • Eisuke Munekata
  • Hiroaki Yamamoto
  • Motoaki Yoshida
  • Takao Nakanishi
  • Pierre Wong
  • André Barbeau
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 139)

Abstract

Methionine enkephalin, the amino acid sequence 61–65 (Tyr-Gly­Gly-Phe-Met) of β-lipotropin, and the related peptide leucine enke­phalin (Tyr-Gly-Gly-Phe-Leu) are endogenous ligands for the opiate receptor in the brain (12). These peptides administered icv in rats (2) and mice (6) possess short-lasting and naloxone-sensitive anal­gesic properties. D-Ala2-Met-enkephalinamide (DAME, Tyr-D-Ala-Gly­Phe-Met-CONH2) is an enkephalin analogue and is pharmacologically similar to morphine and β-endorphin (β-LPH61–91); DAME is more potent in the induction of analgesia than methionine enkephalin (24) and elicits the same catalepsy in rats (29) as β-endorphin (4,17,19, 22) .

Keywords

Dopamine Release Opiate Receptor Corpus Striatum Muscle Rigidity Morphine Analgesia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Barbeau, A., and Huxtable, R.J., eds., “Taurine and Neurological Disorders,” Raven Press, New York (1978).Google Scholar
  2. 2.
    Belluzzi, J.D., Grant, N., Garsky, V., Sarantakis, D., Wise, C.D., and Stein, L., 1976, Analgesia induced in vivo by central administration of enkephalin in rat, Nature (Lond.), 260: 625–626.Google Scholar
  3. 3.
    Biggio, G., Della Bella, D., Frigeni, V., and Guidotti, A., 1977, Potentiation of•morphine analgesia by muscimol, Neuropharmacolo$y, 16: 149–150.Google Scholar
  4. 4.
    Bloom, F., Segal, D., Ling, N., and Guillemin, R., 1976, Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness, Science, 194: 630–632.Google Scholar
  5. 5.
    Bradbury, A.F., Smyth, D.G., Snell, C.K., Deakin, J.F.W., and Wendlandt, S., 1977, Comparison of the analgesic properties of lipotropin C-fragment and stabilized enkephalins in the rat, Biochem. Biophys. Res. Comm., 74:748–754.Google Scholar
  6. 6.
    BUscher, H.H., Hill, R.C., Romer, D., Cardinaux, F., Closse, A., Hauser, D., and Pless, J., 1976, Evidence for analgesic activity of enkephalin in the mouse, Nature (Lond.), 261: 423–425.Google Scholar
  7. 7.
    Chang, J.-K., Fong, B.T.W., Pert, A., and Pert, C.B., 1976, Opiate receptor affinities and behavioral effects of enkephalin: structure-activity relationship of ten synthetic peptide analogues, Life Sci., 18: 1473–1482.PubMedCrossRefGoogle Scholar
  8. 8.
    Collu, R., Charpenet, G., and Clermont, M.J., 1978, Antagonism by taurine of morphine induced growth hormone secretion, Canad. J. Neurol. Sci., 5:139–142.PubMedGoogle Scholar
  9. 9.
    Ferdberg, W. and Smyth, D.G., 1977, C-Fragment of lipotropin - an endogenous potent analgesic peptide, Birt. J. Pharmacol., 60:445–453.Google Scholar
  10. 10.
    Firgeni, V., Bruno, F., Carenzi, A., Racagni, G., and Santini, V., 1978, Analgesia and motor activity elicited by morphine and enkephaline in two inbred strains of mice, 1978, J. Pharm. Pharmacol., 30:310–311.CrossRefGoogle Scholar
  11. 11.
    Ho, I.K., Loh, H.H., and Way, E.L., 1976, Pharmacological manipulation of gamma-aminobutyric acid (GABA) in morphine analgesia, tolerance and physical dependence, Life Sci., 18: 1111–1124.PubMedCrossRefGoogle Scholar
  12. 12.
    Hughes, J., Smith, T.W., Kosterlitz, H.W., Fothergill, L.A., Morgan, B.A., and Morris, H.R., 1975, Identification of two related pentapeptides from the brain with potent opiate agonist activity, Nature (Lond.), 258: 577–579.Google Scholar
  13. 13.
    Huxtable, R., and Barbeau, A., eds., “Taurine,” Raven Press, New York (1976).Google Scholar
  14. 14.
    Iwamoto, E.T., and Way, E.L., Opiate actions and catecholamines, in: “Neurochemical Mechanisms of Opiates and Endorphins,” H.H. Loh and D.H. Ross, eds., Raven Press, New York (1979), pp. 357–407.Google Scholar
  15. 15.
    Izumi, K., Butterworth, R.F., and Barbeau, A., 1977, Effect of taurine on calcium binding to microsomes isolated from rat cerebral cortex, Life Sci., 20: 943–950.PubMedCrossRefGoogle Scholar
  16. 16.
    Izumi, K., Donaldson, J., Minnich, J.L., and Barbeau, A., 1973, Ouabain-induced seizures in rats: suppressive effects of taurine and y-aminobutyric acid, Canad. J. Physiol. Pharmacol., 51: 885–889.CrossRefGoogle Scholar
  17. 17.
    Izumi, K., Motomatsu, T., Chrétien, M., Butterworth, R.F., Lis, M., Seidah, N., and Barbeau, A., (3-Endorphin induced akinesia in rats: effect of apomorphine and a-methyl-p-tyrosine and related modifications of dopamine turnover in the basal ganglia, Life Sci., 20: 1149–1156.Google Scholar
  18. 18.
    Izumi, K., Viallet, C., Barbeau, A., Chrétien, M., and Seidah, N., 1979, Endorphin induced akinesia in rats: a pharmacological study, Clin. Neurol., (Jpn), 19:687–694.Google Scholar
  19. 19.
    Jacquet, Y.F., and Marks, N., 1976, The C-fragment of 6-lipotropin: an endogenous neuroleptic or antipsychotogen? Science, 194: 632–635.Google Scholar
  20. 20.
    Kuriyama, K., Muramatsu, M., Nakagawa, K., and Kakita, K., 1978, Modulating role of taurine on release of neurotransmitters and calcium transport in excitable tissues, in: “Taurine and Neurological Disorders,” A. Barbeau and R.J. Huxtable, eds., Raven Press, New York (1978), pp. 201–216.Google Scholar
  21. 21.
    Loh, H.H., Brase, D.A., Sampath-Khanna, S., Mar, J.B., and Way, E.L., 1976, 6-Endorphin in vitro inhibition of striatal dopamine release, Nature (Lond.), 264: 567–568.CrossRefGoogle Scholar
  22. 22.
    Motomatsu, T., Lis, M., Seidah, N., and Chrétien, M., 1977, Cataleptic effect of 61–91 beta-lipotropic hormone in rat, Canad. J. Neurol. Sci., 4:49–52.PubMedGoogle Scholar
  23. 23.
    Pasantes-Morales, H., and Gamboa, A., 1980, Effect of taurine on 45Ca2+ accumulation in rat brain synaptosomes, J. Neurochem., 34:244–246.PubMedCrossRefGoogle Scholar
  24. 24.
    Pert, C.B., Pert, A., Chang, J.-K., and Fong, B.T.W., 1976, (D-Ala2)-Met-enkephalinamide: a potent, long-lasting synthetic pentapeptide analgesic, Science, 194: 330–332.PubMedCrossRefGoogle Scholar
  25. 25.
    Ross, D.H., and Cardenas, H.L., Nerve cell calcium as a messenger for opiate and endorphin actions, in: “Neurochemical Mechanisms of Opiates and Endorphins, H.H. Loh and D.H. Ross, eds., Raven Press, New York, (1979), pp. 301–336.Google Scholar
  26. 26.
    Subramanian, N., Mitznegg, P., Spriigel, W., Domschke, W., Domschke, S., Wunsch, E., and Demling, L., 1977, Influence of enkephalin on K+-evoked efflux of putative neurotransmitters in rat brain, Naunyn-Schmiedeberg’s Arch. Pharmacol., 299: 163–165.Google Scholar
  27. 27.
    Tseng, L.F., Loh, H.H. and Li, C.H., 1977, Human 6-endorphin: development of tolerance and behavorial activity in rats, Biochem. Biophys. Res. Comm., 74:390–396.Google Scholar
  28. 28.
    Vanderwende, C., and Spoerlein, M.T., 1979, Morphine-induced catalepsy in mice. Modification by drugs acting on neurotransmitter system, Neuropharmacology, 18: 633–637.Google Scholar
  29. 29.
    Wei, E.T., Tseng, L.F., Loh, H.H., and Li, C.H., 1977, Comparison of the behavorial effects of 6-endorphin and enkephalin analogs, Life Sci., 21: 321–328.Google Scholar
  30. 30.
    Yoneda, Y., Takashima, S., and Kuriyama, K., 1976, Possible involvement of GABA in morphine analgesia, Biochem. Pharmacol., 25:2669–2670.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Kanji Izumi
    • 1
  • Eisuke Munekata
    • 2
  • Hiroaki Yamamoto
    • 3
  • Motoaki Yoshida
    • 1
  • Takao Nakanishi
    • 1
  • Pierre Wong
    • 4
  • André Barbeau
    • 4
  1. 1.Department of Neurology Institute of Clinical MedicineUniversity of TsukubaIbaraki 305Japan
  2. 2.Institute of Applied BiochemistryUniversity of TsukubaIbaraki 305Japan
  3. 3.Institute of Community MedicineUniversity of TsukubaIbaraki 305Japan
  4. 4.Department of NeurobiologyClinical Research Institute of MontrealCanada

Personalised recommendations