Central Neuropharmacology of D-Ala2-Met-Enkephalinamide and its Interactions with Taurine in Rats

  • Kanji Izumi
  • Eisuke Munekata
  • Hiroaki Yamamoto
  • Motoaki Yoshida
  • Takao Nakanishi
  • Pierre Wong
  • André Barbeau
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 139)


Methionine enkephalin, the amino acid sequence 61–65 (Tyr-Gly­Gly-Phe-Met) of β-lipotropin, and the related peptide leucine enke­phalin (Tyr-Gly-Gly-Phe-Leu) are endogenous ligands for the opiate receptor in the brain (12). These peptides administered icv in rats (2) and mice (6) possess short-lasting and naloxone-sensitive anal­gesic properties. D-Ala2-Met-enkephalinamide (DAME, Tyr-D-Ala-Gly­Phe-Met-CONH2) is an enkephalin analogue and is pharmacologically similar to morphine and β-endorphin (β-LPH61–91); DAME is more potent in the induction of analgesia than methionine enkephalin (24) and elicits the same catalepsy in rats (29) as β-endorphin (4,17,19, 22) .


Dopamine Release Opiate Receptor Corpus Striatum Muscle Rigidity Morphine Analgesia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Kanji Izumi
    • 1
  • Eisuke Munekata
    • 2
  • Hiroaki Yamamoto
    • 3
  • Motoaki Yoshida
    • 1
  • Takao Nakanishi
    • 1
  • Pierre Wong
    • 4
  • André Barbeau
    • 4
  1. 1.Department of Neurology Institute of Clinical MedicineUniversity of TsukubaIbaraki 305Japan
  2. 2.Institute of Applied BiochemistryUniversity of TsukubaIbaraki 305Japan
  3. 3.Institute of Community MedicineUniversity of TsukubaIbaraki 305Japan
  4. 4.Department of NeurobiologyClinical Research Institute of MontrealCanada

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