Specific Binding of Taurine in Central Nervous System
Taurine (2-aminoethanesulfonic acid) is present in the central nervous system (CNS) in high concentration and satisfies some of the criteria essential for identification as a neurotransmitter. These are high affinity uptake of taurine into synaptosomes or brain slices (6,18), the release of taurine from brain slices and synaptosomes by electrical stimulation or high concentrations of potassium ion (3,4,6,9,10) and specific binding of taurine to brain synaptic membranes (7,8,11,19). Furthermore, taurine has been shown to be bound to (19) and taken up by glial cells, suggesting that glial cells are involved in the functional role of taurine in CNS.
KeywordsGlial Cell Specific Binding Synaptic Membrane Transport Site Synaptic Region
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