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Specific Binding of Taurine in Central Nervous System

  • Tomio Segawa
  • Atsuko Inoue
  • Takehiro Ochi
  • Yoshihiro Nakata
  • Yasuyuki Nomura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 139)

Abstract

Taurine (2-aminoethanesulfonic acid) is present in the central nervous system (CNS) in high concentration and satisfies some of the criteria essential for identification as a neurotransmitter. These are high affinity uptake of taurine into synaptosomes or brain slices (6,18), the release of taurine from brain slices and synaptosomes by electrical stimulation or high concentrations of potassium ion (3,4,6,9,10) and specific binding of taurine to brain synaptic membranes (7,8,11,19). Furthermore, taurine has been shown to be bound to (19) and taken up by glial cells, suggesting that glial cells are involved in the functional role of taurine in CNS.

Keywords

Glial Cell Specific Binding Synaptic Membrane Transport Site Synaptic Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Tomio Segawa
    • 1
  • Atsuko Inoue
    • 1
  • Takehiro Ochi
    • 1
  • Yoshihiro Nakata
    • 1
  • Yasuyuki Nomura
    • 1
  1. 1.Department of Pharmacology Institute of Pharmaceutical SciencesHiroshima University School of MedicineHiroshima 734Japan

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