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Taurine Receptors in CNS Membranes: Binding Studies

  • A. M. López-Colomé
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 139)

Abstract

Taurine is present in high concentration in a wide variety of animal tissues (26), especially in excitable and nervous tissue (34,40,45). Recently, great interest has developed in clarifying the function of taurine in the central nervous system. It has been demonstrated that taurine, which is present in the brain in high concentrations (40), has a hyperpolarizing effect on neurons from the spinal cord and cerebral cortex when iontophoretically applied (6–8). It also has been shown to depress reversibly the b wave of the electroretinogram (47,62). A high-affinity, sodium-dependent uptake system has been demonstrated for taurine accumulation into brain slices and into a specific synaptosomal subfraction (24,28,29,57). It has been reported that taurine is released from cerebral cortex in response to electrical stimulation (32) and from the retina upon the influence of light (48,55). Furthermore the release of taurine following depolarizing stimuli has also been demonstrated in rat brain and spinal cord slices as well as in mouse brain synaptosomes (3,4,27,32,36). These findings support the hypothesis that taurine might act as an inhibitory transmitter or a modulator in the central nervous system (9,39).

Keywords

Olfactory Bulb Postsynaptic Receptor Gaba Binding Crude Synaptosomal Fraction Brain Synaptic Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • A. M. López-Colomé
    • 1
  1. 1.Departamento de Neurociencias Centro de Investigaciones en Fisiología CelularUniversidad Nacional Autónoma de MéxicoMéxico 20, D.FMéxico

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