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Changed Taurine-Glutamic Acid Content and Altered Nervous Tissue Cytoarchitecture

  • Nico M. Van Gelder
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 139)

Abstract

Despite the efforts of numerous investigators, it appears difficult at this time to assign in mammals any definite biological role to taurine. Nevertheless, the special association of taurine with electrically excitable tissue (heart, muscle and CNS) supposes its importance in the process of conduction and/or synaptic transmission. In these organs taurine seems involved in, among other phenomena, the regulation of calcium metabolism, temperature control as well as in the maintenance of the compartmentalized metabolism of glutamic acid, and other amino acids, whose metabolism and sequestration require a combination of neuronal and glial elements. Other findings suggest that the amino acid may perform a critical function in neonatal and, perhaps, embryonic development of the central nervous system (2,15). The latter suggestion is further supported by the fact that in women, taurine excretion becomes sharply curtailed during the period of pregnancy and lactation (1). That its role in assuring proper cellular “development” is not confined to nervous tissue may be extrapolated from findings that a similar diminished excretion of taurine occurs during wound healing (36). Other conditions such as radiation damage (14), hormonal imbalance (7,8), the viability of tissue cultures (13) and certain disease states (16,17) also appear reflected by alterations in taurine excretion or tissue taurine content, The possible function of taurine in such critical biological phenomena assumes even greater significance when it is con-sidered in the context of findings indicating that in man and a number of other species the amino acid probably remains essential nutrient throughout life (19). Temporary or chronic dietary deficiencies as well as certain drugs, an acquired or familial tendency for high taurine excretion, and the physical condition of the individual, may therefore all represent important factors in the prevention or reversal by taurine of cytoarchitectural or functional damage in organs and tissues (21,22,23,33,35).

Keywords

Glutamic Acid Nervous Tissue Neuronal Element Taurine Level Taurine Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Armstrong, M.D., 1973, Decreased taurine excretion in relation to childbirth, lactation and progestin-estrogen therapy, Clin. Chim. Acta 46:253–256.PubMedCrossRefGoogle Scholar
  2. 2.
    Barbeau, A., and Huxtable, R., eds., Taurine and Neurological Disorders; various chapters, Raven Press, New York (1978).Google Scholar
  3. 3.
    Berl, S., Clarke, D.D., and Schneider, D., eds., in: “Metabolic compartmentation and neurotransmission: Relation to brain structure and function,” Plenum Press, New York (1975).Google Scholar
  4. 4.
    Berl, S., Lajtha, A., and Waelsch, H., 1961, Amino acid and protein metabolism - VI Cerebral compartments of glutamic acid metabolism, J. Neurochem. 7:186–197.CrossRefGoogle Scholar
  5. 5.
    Cremer, J.E., Changes within metabolic compartments related to the functional state and the action of drugs on the whole brain, in: “Metabolic compartmentation in the brain,” R. Balasz and J.E. Cremer, eds., MacMillan Press, New York (1973), pp. 81–93.Google Scholar
  6. 6.
    Dodd, P.R., Bradford, H.F., Abdul-Ghani, A.S., Cox, D.W.G., and ContinhoNetto, J., 1980, Release of amino acids from chronic epileptic and subepileptic foci in vivo, Brain Res., 193: 505–517.Google Scholar
  7. 7.
    Hellstrom, K., and Schuberth, J., 1970, The effect of thyroid hormones on the urinary excretion of taurine in man, Acta Med. Scand. 187:61–65.PubMedCrossRefGoogle Scholar
  8. 8.
    Jacobsen, J.G., and Smith, L.H., 1968, Biochemistry and physiology of taurine and taurine derivatives, Physiol. Rev. 48: 424–511.Google Scholar
  9. 9.
    Koyama, I., 1972, Amino acid content in the cobalt-induced epileptogenic and non-epileptogenic cat’s cortex, Can. J. Physiol. Pharmacol. 50:740–752.PubMedCrossRefGoogle Scholar
  10. 10.
    Koyama, I., and Jasper, H.H., 1977, Amino acid content of chronic undercut cortex of the cat in relation to electrical after discharge: Comparison with cobalt epileptogenic lesions, Can. J. Physiol. Pharmacol. 55:523–536.PubMedCrossRefGoogle Scholar
  11. 11.
    Kvamme, E, Regulation of glutaminase and its possible implication for GABA metabolism, in: “GABA–Biochemistry and CNS function,” P. Mandel and F.V. De Feudis, eds., Plenum Press, New York (1979), pp. 111–138.Google Scholar
  12. 12.
    Laidlaw, J., and Richens, A., eds., A textbook of epilepsy, Churchill Livingstone, New York, (1976) pp. 66–108; 314–354.Google Scholar
  13. 13.
    Piez, K.A., and Eagle, H., 1958), The free amino acid pool of cultured human cells, J. Biol. Chem. 237:533–545.Google Scholar
  14. 14.
    Raghavan, K.G., and Nadkarni, G.B., 1970, Formation and excretion of taurine in X-irradiated rats, Int. J. Radiat. Biol. 18:41–49.CrossRefGoogle Scholar
  15. 15.
    Rassin, D.K., and Gaull, G.E., Taurine and other sulphur containing amino acids: Their function in the central nervous system, in: “Amino acid as chemical transmitter,” F. Fonnum, ed., Plenum Press, New York, (1978), pp. 571–597.CrossRefGoogle Scholar
  16. 16.
    Rylance, H.J., 1969, Hypertaurinuria in rheumatoid arthritis, Ann. Rheum. Dis. 28:41–44.PubMedCrossRefGoogle Scholar
  17. 17.
    Rylance, H.J., and Myhal, D.R., 1971, Taurine excretion and the influence of drugs, Clin. Chim. Acta 35:159–164.PubMedCrossRefGoogle Scholar
  18. 18.
    Schousboe, A., and Divac, I., 1979, Differences in glutamate uptake in astrocytes cultured from different brain regions, Brain Res. 177: 407–409.Google Scholar
  19. 19.
    Sturman, J.A., 1977, Taurine in nutrition, Comp. Ther. 3:59–65.Google Scholar
  20. 20.
    Tursky, T., Ruscak, M., and Lassanova, 1979, Effect of experimentally elicited astroglia proliferation on two compartments of glutamate metabolism in rat brain cortex slices, Physiol. Bohemoslov. 28:43–49.PubMedGoogle Scholar
  21. 21.
    van Gelder, N.M., 1972, Antagonism by taurine of cobalt-induced epilepsy in cat and mouse, Brain Res. 47: 157–165.Google Scholar
  22. 22.
    van Gelder, N.M., Rectification of abnormal glutamic acid levels by taurine, in: “Taurine”, R. Huxtble and A. Barbeau, eds., Raven Press, New York (1976), pp. 293–302.Google Scholar
  23. 23.
    van Gelder, N.M., Glutamic acid and epilepsy: the action of taurine, in: “Taurine and neurological disorders,” A. Barbeau and R. Huxtable, eds., Raven Press, New York, (1978a), pp. 45–54.Google Scholar
  24. 24.
    van Gelder, N.M., ed., (1978b), Taurine, the compartmentalized metabolism of glutamic acid and the epilepsies, Can J. Physiol. Pharmacol. 56:362–374.Google Scholar
  25. 25.
    van Gelder, N.M., The biochemistry of hyperexcitability: Normal versus epileptic state, in: “Advances in epileptology: 11th Epilepsy International Symposium”, R. Canger, F. Angeleri and J.K. Penry, eds., Raven Press, New York, (1980), pp. 285–288.Google Scholar
  26. 26.
    van Gelder, N.M., 1980, Glutamic acid metabolism and epilepsy. Neurosciences 6, (Suppl. 1): 163–177.Google Scholar
  27. 27.
    van Gelder, N.M., Glutamic acid in nervous tissue and changes of taurine content: Its implication in the treatment of epilepsy, in: “Amino acid transmitters,” P. Mandel and F.V. De Feudis, eds., Raven Press, New York, in pres:~.Google Scholar
  28. 28.
    van Gelder, N.M., Aslam-Janjua, N., Metrakos, K., MacCibbon, B., and Metrakos, J.D., 1980, Serum amino acids in 3/sec spike-wave epilepsy, Neurochem. Res. 5:659–671.PubMedCrossRefGoogle Scholar
  29. 29.
    van Gelder, N.M., and Courtois, A., 1972, Close correlation between changing content of specific amino acids in epileptogenic cortex of cats, and severity of epilepsy, Brain Res. 43: 477–484.PubMedCrossRefGoogle Scholar
  30. 30.
    van Gelder, N.M., and Drujan, B.D., 1978, Interrelated changes of amino acids in the retina and optic tectum of a marine fish with alterations of illuminating conditions, Brain Res. 159: 137–148.PubMedCrossRefGoogle Scholar
  31. 31.
    van Gelder, N.M., and Drujan, B.D., 1980, Alterations in the compartmentalized metabolism of glutamic acid with changed cerebral conditions, Brain Res. 200: 443–455.PubMedCrossRefGoogle Scholar
  32. 32.
    van Gelder, N.M., Edmonds, H.L., Hegreberg, G.A., Chatburn, C.C., Clemmons, R.M., and Sylvester, D.M., 1980, Amino acid changes in a genetic strain of epileptic beagle dogs, J. Neurochem. 35: 1087–1091.PubMedCrossRefGoogle Scholar
  33. 33.
    van Gelder, N.M., Koyama, I., and Jasper, H., 1977, Taurine treatment of spontaneous chronic epilepsy in a cat, Epilepsia 18: 45–54.Google Scholar
  34. 34.
    van Gelder, N.M., Sherwin, A.L., and Rasmussen, T., 1972, Amino acid content of epileptogenic human brain: focal versus surrounding regions, Brain Res. 40: 385–393.PubMedCrossRefGoogle Scholar
  35. 35.
    van Gelder, N.M., Sherwin, A.L., Sacks, C., and Andermann, F., 1975, Biochemical observations following administration of taurine to patients with epilepsy, Brain Res.94:297–306.Google Scholar
  36. 36.
    Williamson, M.B., and Passman, J.M., 1960, Excretion of taurine during healing of experimental wounds, Clin. Chem. 6:140–147.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Nico M. Van Gelder
    • 1
  1. 1.Centre de recherche en sciences neurologiques Département de physiologie Faculté de médecineUniversité de MontréalMontréalCanada

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