Elevated Blood Taurine Levels After Myocardial Infarction or Cardiovascular Surgery: Is There Any Significance?
Though it is well known that cardiac tissue contains large quantities of taurine the function of taurine in the myocardium has not been defined. In rat cardiac tissue the content of taurine comprises over 50% of the total free amino acids (9) with a level of approximately 100 μmoles/g dry weight (12). Not only is cardiac tissue high in taurine content but there is also an unequal distribution throughout the myocardium. For example, it has been reported by both Kocsis and colleagues (10) and Crass and Lombardini (1) that atrial taurine content is significantly higher than ventricular content in the dog heart. Furthermore, both laboratories reported that a transmural gradient existed in the dog left ventricle with the highest taurine content being present in the subendocardium (1,10). While there are few reports of taurine content in human heart it appears that our species is no different from the rest of the animal kingdom in that we also harbor high levels of taurine in our cardiac tissue (7,8). Furthermore, the disparity in regional distribution of taurine in the human heart has been noted in our laboratory. However, the human heart differs from the dog heart in that the ventricular content of taurine is higher than the atrial content (unpublished observations).
KeywordsPermeability Ischemia Anemia Bicarbonate Epinephrine
Unable to display preview. Download preview PDF.
- 2.Crass, M.F., III and Lombardini, J.B., 1978, Release of tissue taurine from the oxygen-deficient perfused rat heart, Proc. Soc. Exp. Biol. Med. 157, 486.Google Scholar
- 5.Gaut, Z.N. and Nauss, C.B., 1976, Uptake of taurine by human blood platelets: a possible model for brain, In Taurine, edited by Huxtable, R. and Barbeau, A., New York, Raven Press, pp 91–98.Google Scholar
- 9.Jacobsen, J.G. and Smith, L.H., Jr., 1968, Biochemistry and physiology of taurine and taurine derivatives, Physiol. Reviews 48, 424–511.Google Scholar
- 10.Kocsis, J.J., Kostos, V.J. and Baskin, S.T., 1976, Taurine levels in the heart tissues of arious species, In Taurine, edited by Huxtable, R. and Barbeau, A., New York, Raven Press, pp 145–153.Google Scholar
- 12.Lombardini, J.B., 1980, Effects of isoproterenol and methoxamine on the contents of taurine in rat tissues, J. Pharmacol. Exp. Ther. 213, 399–405.Google Scholar
- 14.Rona, G., Bontet, M., Huttner, I. and Peters, K., 1973, Pathogenesis of isoproterenol-induced myocardial alterations: Functional and morphological correlates, In Recent Advances in Studies on Cardiac Structure and Metabolism, edited by Dhalla, N.S., vol. 3, University Park Press, Baltimore, pp 507–525.Google Scholar
- 15.Rona, G., Chappel, C.K., Balazs, T. and Gaudry, R, 1959, An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat, Arch. Pathol. 67, 443–455.Google Scholar