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Lipophilicity and the Pharmacokinetics of Nitroimidazoles

  • Paul Workman
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 43)

Abstract

The processes of absorption, distribution and elimination are vitally important in all drug therapy, for collectively they determine the drug concentrations present at the sites of toxic and therapeutic effects. Pharmacokinetic considerations are especially critical for drugs with low therapeutic ratios, e.g. antineoplastic agents. The pharmacokinetics of nitroimidazole radiosensitizers have been reviewed recently (1). Considerable evidence now shows that all aspects of the pharmacokinetics of nitroimidazoles (as for other drugs) are strongly influenced by lipophilicity. The aim in this paper is to discuss the pharmacokinetics of nitroimidazole drugs with particular emphasis on this important property.

Keywords

Partition Coefficient Hypoxic Cell Lipophilic Drug Hydrophilic Drug Therapeutic Ratio 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Paul Workman
    • 1
  1. 1.MRC Clinical Oncology and Radiotherapeutics UnitThe Medical SchoolCambridgeEngland

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