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Advanced Topics on Radiosensitizers of Hypoxic Cells pp 143–163Cite as

Lipophilicity and the Pharmacokinetics of Nitroimidazoles

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Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 43))

Abstract

The processes of absorption, distribution and elimination are vitally important in all drug therapy, for collectively they determine the drug concentrations present at the sites of toxic and therapeutic effects. Pharmacokinetic considerations are especially critical for drugs with low therapeutic ratios, e.g. antineoplastic agents. The pharmacokinetics of nitroimidazole radiosensitizers have been reviewed recently (1). Considerable evidence now shows that all aspects of the pharmacokinetics of nitroimidazoles (as for other drugs) are strongly influenced by lipophilicity. The aim in this paper is to discuss the pharmacokinetics of nitroimidazole drugs with particular emphasis on this important property.

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Author information

Authors and Affiliations

  1. MRC Clinical Oncology and Radiotherapeutics Unit, The Medical School, Hills Road, Cambridge, CB2 2QH, England

    Paul Workman

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  1. Paul Workman
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Editor information

Editors and Affiliations

  1. University of Bologna, Bologna, Italy

    A. Breccia

  2. Malpighi Hospital, Bologna, Italy

    C. Rimondi

  3. Institute of Cancer Research, Sutton, England

    G. E. Adams

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© 1982 Plenum Press, New York

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Workman, P. (1982). Lipophilicity and the Pharmacokinetics of Nitroimidazoles. In: Breccia, A., Rimondi, C., Adams, G.E. (eds) Advanced Topics on Radiosensitizers of Hypoxic Cells. NATO Advanced Study Institutes Series, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0399-3_7

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  • DOI: https://doi.org/10.1007/978-1-4757-0399-3_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0401-3

  • Online ISBN: 978-1-4757-0399-3

  • eBook Packages: Springer Book Archive

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