Radiation-Induced Cellular DNA Damage and Repair, and the Effect of Hypoxic Cell Radiosensitizers
Chromosomal deoxyribonucleic acid (DNA) is accepted as an important target for radiochemical damage in biological systems following ultraviolet and ionizing irradiation. Several types of experimental data support this hypothesis for numerous biological systems including both mammalian and bacterial cells. The isolation and consequent studies on several mutant strains of Escherichia coli of differing DNA repair capabilities (1,2) have helped to clarify the role of DNA as a primary target and has revealed the significance of post-irradiation cellular repair activity (Table 1).
KeywordsExcision Repair Single Strand Break Strand Separation Oxygen Enhancement Ratio Ionize Radiation Damage
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