Molecular Structure and Biological Activity of Hypoxic Cell Radiosensitizers and Hypoxic-Specific Cytotoxins

  • Peter Wardman
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 43)


It has been suggested (1) that if we were to seek an anticancer drug by randomly testing compounds, some 400 million compounds might need to be examined before a successful drug were found. This paper outlines briefly some of the methods which should prove useful in optimising the chemical properties of a series of compounds in which some activity has been demonstrated, thus reducing the burden to perhaps one-millionth of that which would otherwise be necessary. We shall also comment on the problem of identifying potential ‘new-lead’ compounds, where the basis for potential activity is not well understood, as distinct from optimising the properties of an already active series.


Partition Coefficient Nitro Compound Hypoxic Cell Radiation Sensitizer Pulse Radiolysis 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Peter Wardman
    • 1
  1. 1.Cancer Research Campaign Gray LaboratoryMount Vernon HospitalNorthwood, MiddlesexEngland

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