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Multiple Daily Fractionation (MDF) in Association with Misonidazole (MIS): A Two-Year Experience with Head and Neck Cancer

  • G. Arcangeli
  • F. Mauro
  • C. Nervi
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 43)

Abstract

In our Institution MDF schemes have been introduced several years ago (1,2). One of the main reasons for developing and testing this kind of scheme is the possibility of compressing the radiation dose in time, thus allowing a better exploitation of hypoxic cell radiosensitizers administration within the well-known toxicity limits. Further, other radiobiological criteria may justify the use of non-conventional fractionation per se (and of local hyperthermia) on radioresistant tumours with a presumably high fraction of hypoxic cells.

Keywords

Multimodality Treatment Hypoxic Cell Conventional Fractionation Historical Series Neck Node Metastasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • G. Arcangeli
    • 1
  • F. Mauro
    • 2
  • C. Nervi
    • 1
  1. 1.Istituto Medico e di Ricerca ScientificaRomeItaly
  2. 2.Comitato Nazionale per l’Energia NucleareRomeItaly

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