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The Design of Clinical Trials and Clinical Toxicology of the Nitroimidazole Misonidazole in Phase I Testing in the Radiation Therapy Oncology Group

  • Theodore L. Phillips
  • Todd H. Wasserman
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 43)

Abstract

The Radiation Therapy Oncology Group (RTOG) is the only organized cooperative group within the United States dedicated to the investigation of therapeutic radiology in the treatment of malignant disease. More than 25 institutions have joined together with support from the National Cancer Institute for a series of cooperative clinical trials in a number of disease sites and a wide range of new modalities. The goal of the RTOG is to improve the results of radiotherapy in the cure of cancer and in the palliation of metastatic disease.

Keywords

Radiation Therapy Oncology Group Central Nervous System Effect Clinical Toxicology Central Nervous System Toxicity Grade Grade 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    T. L. Phillips, T. H. Wasserman, R. J. Johnson The hypoxic cell sensitizer program in the United States, Br. J. Cancer 37:suppl. III:276 (1978).Google Scholar
  2. 2.
    T. L. Phillips, and T. H. Wasserman, Hypoxic cell sensitizer studies in the U.S., in: “Treatment of Radioresistant Cancers”, Elsevier, North Holland Press, pp. 29–40 (1979).Google Scholar
  3. 3.
    T. L. Phillips, T. H. Wasserman, R. J. Johnson, Final report on the United States Phase I clinical trial of the hypoxic cell radiosensitizer misonidazole. Submitted to Cancer (1980).Google Scholar
  4. 4.
    T. H. Wasserman, T. L. Phillips, R. J. Johnson, Initial U.S. clinical and pharmacologic evaluation of misonidazole, an hypoxic cell radiosensitizer, Int. J. Radiat. Oncol. Biol. Phys. 5:775 (1979).PubMedCrossRefGoogle Scholar
  5. 5.
    T. H. Wasserman, R. Urtasun, and J. Schwade, The neurotoxicity of misonidazole. Potential modifying role of Phenytoin sodium and dexamethasone, Brit. J. Radiol. 53:173 (1980).CrossRefGoogle Scholar
  6. 6.
    T. H. Wasserman, J. Stetz, and T. L. Phillips, Clinical trials of misonidazole in the United States, Cancer Clinical Trials, in press, (1980).Google Scholar
  7. 7.
    G. VanRaalte, T. L. Phillips, and T. H. Wasserman, (Abstract), Int. J. Radiat. Oncol. Biol. Phys., in press, (1980).Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Theodore L. Phillips
    • 1
    • 2
  • Todd H. Wasserman
    • 1
    • 2
  1. 1.Department of Radiation OncologyUniversity of California San FranciscoUSA
  2. 2.Department of Radiation OncologyWashington University School of MedicineUSA

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