Subendocardial Ischemia in the Absence of Coronary Artery Disease

  • J. I. E. Hoffman
  • R. W. Baer
  • P. N. Uhlig
  • G. J. Vlahakes
  • J. D. Bristow
  • L. M. Messina
  • F. L. Hanley
  • E. D. Verrier
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 62)


When people with coronary atherosclerosis develop angina pectoris or do strenuous exercise, their electrocardiograms frequently show in the left precordial leads ST segment depression that is generally ascribed to subendocardial ischemia. Similar electrocardiographic changes have been seen in patients with severe aortic stenosis or incompetence, or severe right ventricular hypertension, even when the coronary arteries are normal. In 1955 Marquis and Logan showed that patients with congenital aortic stenosis and electrocardiographic signs of subendocardial ischemia had subendocardial necrosis and fibrosis in the left ventricle, and suggested that the damage was ischemic in origin. Their findings have been confirmed many times since then (Moller, Nakeb and Edwards, 1966; Schwarz, Flameng, Schaper et al., 1978; Cheitlin, Robinowitz, McAllister et al., 1980).


Coronary Sinus Coronary Flow Tissue Pressure Superficial Muscle Collapsible Tube 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • J. I. E. Hoffman
    • 1
  • R. W. Baer
    • 1
  • P. N. Uhlig
    • 1
  • G. J. Vlahakes
    • 1
  • J. D. Bristow
    • 1
  • L. M. Messina
    • 1
  • F. L. Hanley
    • 1
  • E. D. Verrier
    • 1
  1. 1.Cardiovascular Research Institute and the Departments of Pediatrics, Physiology, Internal Medicine and SurgeryUniversity of CaliforniaSan FranciscoUSA

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