Advertisement

Microcirculation in Myocardium and Cerebral Cortex

  • Richard J. Bing
  • Bing-Lo Chang
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 62)

Abstract

The cerebral microcirculation has been studied by a variety of methods. Most of the early findings were based on histological observations. Craigie (1921) studied the vascularity of the cerebral cortex of the rat with microscopic techniques and Florey (1925) stimulated by Sherrington’s observations, used Indian ink injections to outline cerebral microcirculation. Dunning and Wolfe (1937) injected Berlin blue, and by histological observations determined the vascularity of the parietal cortex. Using radiographic as well as tissue transparency, Rowbotham (1967) observed blood supply of the cerebral hemisphere and the white matter. Haswegawa (1967) by metallic impregnation, discovered precapillary thoroughfare channels in the cerebral cortex.

Keywords

Cerebral Cortex Cerebral Blood Flow Systemic Blood Pressure Capillary Length Circulation Research 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. BAYLISS, W.M. (1902): On the local action of the arterial wall to changes of internal pressure. J. Physiol. 28: 220–231.Google Scholar
  2. BING, R.J., and CHANG, B.L. (1982): Advances in Experimental Medicine and Biology. J.J. Spitzer, Plenum Press, New York, in press.Google Scholar
  3. BOURDEAU-MARTINI, J., and HONIG, C.R. (1973): Control of coronary intercapillary distance: Effect of arterial PCO2 and pH. Microvasc. Res. 6: 286–296.CrossRefGoogle Scholar
  4. CHAMBERS, R., and ZWEIFACH, B.W. (1946): Functional activity of the blood capillary bed, with special reference to visceral tissue. Ann. NY. Acad. Sci. 46:683.CrossRefGoogle Scholar
  5. CHANG, B.L., YAMAKAWA, T., NUCCIO, J., PACE, R., and BING, R.J. (1982): Microcirculation of left atrial muscle, cerebral cortex and mesentery of the cat. Circ. Res. 50: 240–249.Google Scholar
  6. CRAIGIE, E.H. (1921): The vascularity of the cerebral cortex of the Albino rat. J. Comp. Neurol. 33:193.CrossRefGoogle Scholar
  7. DUNNING, H.S., and WOLFF, H.G. (1937): The relative vascularity of various parts of the central and peripheral nervous system of the cat and its relation to function. J. Comp. Neurol. 67: 433–450.CrossRefGoogle Scholar
  8. EDVINSSON, L., and MACKENZIE, E.T. (1977): Amine mechanisms in the cerebral circulation. Pharmacol. Reviews 28: 275–348.Google Scholar
  9. FLOREY, H. (1925): Microscopical observations on the circulation of the blood in the cerebral cortex. Brain 48: 43–64.CrossRefGoogle Scholar
  10. GILMAN, A.G., GOODMAN, L.S., and GILMAN, A. (1980): The Pharmacological Basis of Therapeutics, ed 6. New York, Macmillan Publishing Co.Google Scholar
  11. HASEGAWA, T., RAVENS, J.R., and TOOLE, J.F. (1967): Precapillary arteriovenous anastomoses. Arch. Neurol. 16: 217–224.CrossRefGoogle Scholar
  12. HERNANDEX, M.J., BRENNAN, R.W., and BOWMAN, G.S. (1978): Cerebral blood flow autoregulation in the rat. Stroke 9: 150–155.CrossRefGoogle Scholar
  13. KALININA, M.K., and KEVKOVICH, Yu. I., IVANOV, K.P., and TRUSOVA, V.K. (1976): Blood flow velocity in cerebral cortex capillaries (microcinephotographic study), Dokl. Akad. Nauk. S.S.S.R., 226: 230–233.Google Scholar
  14. KONTOS, H.A., WEI, E.P., RAPER, A.J., and PATTERSON, J.L. (1977): Local mechanism of CO2 action on cat pial arterioles. Stroke 8: 226–229.CrossRefGoogle Scholar
  15. LASSEN, N.A., and CHRISTENSEN, M.S. (1976): Physiology of cerebral blood flow. Brit. J. Anaesth. 48: 719–734.CrossRefGoogle Scholar
  16. LUBBERS, D.W. (1976): Quantitative measurement and description of oxygen supply to the tissue. In: Oxygen and Physiological Function. F.F. Jobsis (Ed.). Dallas, Professional Information Library, pp. 254–274.Google Scholar
  17. MA, Y.P., KOO, A., KWAN, H.C., and CHENG, K.K. (1974): On-line measurement of the dynamic velocity of erythrocytes in the cerebral microvessels in the rat. Microvasc. Res. 8:1–13.CrossRefGoogle Scholar
  18. MACKENZIE, E.T., STRANDGAARD, S., GRAHAM, D.I., JONES, J.V., HARPER, A.M., and FARRAR, J.K. (1976): Effects of acutely induced hyper-tension in cats on pial arteriolar caliber, local cerebral blood flow, and the blood-brain barrier. Circ. Res. 39: 33–41.Google Scholar
  19. MCDOWALL, D.G. (1965): The effects of general anaesthetics on cerebral blood flow and cerebral metabolism. Brit. J. Anaesth. 37: 236–245.CrossRefGoogle Scholar
  20. MCHEDLISHVILI, G.I., NIKOLAISHVILI, L.S., and ANITA, R.V. (1976): Are the pial arterial responses dependent on the direct effect of intravascular pressure and extravascular and intravascular PO2, PCO2 and pH Microvasc. Res. 10: 298–311.CrossRefGoogle Scholar
  21. OPITZ, E., and SCHNEIDER, M. (1950): Uber die Sauerstoffversorgung des Gehirns und den Mechanismus von Mangelwirkungen. Ergeb. Physiol. 4: 126–203.Google Scholar
  22. PAWLIK, G., RACKL, A., and BING, R.J. (1981): Quantitative capillary topography and blood flow in the cerebral cortex of cats: an in vivo microscopic study. Brain. Res. 208: 35–58.CrossRefGoogle Scholar
  23. PIERCE, E.C., LANEITSEN, C.J., DEUTSCH, S., CHASE, P.E., LINDE, H.W., DRIPPS, R.D., and PIERCE, H.L. (1962): Cerebral circulation and metabolism during tiopental anaesthetic and hyperventilation in man. J. Clinc. Invest. 41: 1664–1671.CrossRefGoogle Scholar
  24. REBATEL, F. (1872): Recherches experimentales sur la circulation dans les arteres coronaires. Theses (288), Paris. Quoted from R.J. Bing: Coronary circulation and cardiac metabolism. In Circulation of the Blood: Men and Ideas, A.P. Fishman and D.W. Richards. (Eds.). New York, Oxford University Press. 1964, p. 235.Google Scholar
  25. REIVICH, M. (1974): Brain disfunction in metabolic disorders. Res. Nerv. Ment. Dis. 53: 125–140.Google Scholar
  26. ROSENBLUM, W.I., and KONTOS, H.A. (1974): The importance and relevance of studies of the pial microcirculation. Stroke 5: 425–428.CrossRefGoogle Scholar
  27. ROTH, J.A., GREENFIELD, A.J., KAIHARA, S., and WAGNER, H.H. J.R., (1970): Total and regional cerebral blood flow in unanesthetized dogs. Am. J. Physiol. 219: 96–101.Google Scholar
  28. ROWBOTHAM, G.F., and LITTER, E. (1965): Circulation of the cerebral hemispheres. Brit. J. Surg., 52:8.CrossRefGoogle Scholar
  29. SATO, M., NAGAO, T., YAMAGUCHI, I., NAKAJIMA, H., and KIYOMOTO, A. (1971): Pharmacological studies on a new 1,5 — Benzothiazepine derivative. (CRD-401). Arzneim. Forsch. (Drug-Res) 21: 1338–1343.Google Scholar
  30. SOKOKOFF, L. (1977): Relation between physiological function and energy metabolism in the central nervous system. J. Neurochem. 29: 13–26.CrossRefGoogle Scholar
  31. TILLICH, G., MENDOZA, L., WAYLAND, H. and BING, R.J. (1971): Studies of the coronary microcirculation of the cat. Am. J. Cardiol. 27: 93–98.CrossRefGoogle Scholar
  32. TILLMANNS, H., IKEDA, S., HANSEN, H., SARMA, J.S.M., FAUVEL, J.M. and BING, R.J. (1974): Microcircultion in the ventricle of the dog and turtle. Circ. Res. 34: 561–569.Google Scholar
  33. UNDERWOOD, E.E. (1970): Quantitative Stereology. Addison-Wesley, Reading, Mass.Google Scholar
  34. WOLLMAN, H., ALEXANDER, C., COHEN, P.J., SMITH, T.C., CHASE, P.E., and van der MOTEN, R. (1965): Cerebral circulation during general anesthesia and hyperventilation in man. Anesth. 26: 329–334.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Richard J. Bing
    • 1
  • Bing-Lo Chang
    • 1
  1. 1.Department of Experimental Cardiology, Huntington Medical Research InstitutesThe Huntington Memorial HospitalPasadenaUSA

Personalised recommendations