The maintenance of normal heart function and metabolic status requires adequate perfusion, otherwise myocardial ischemia will develop. While progress has been made in this many faceted area of investigation by the use of multidisciplinary approaches ranging from the fundamental to the purely clinical, relatively little is still known about the actual etiology of many cardiovascular dysfunctions, Improved diagnosis and management of cardiovascular disease has resulted in a decline in mortality but not in the number of productive man hours lost through myocardial infarcts and other serious conditions. A wealth of information has been obtained at the organ, blood vessel/tissue, cellular and molecular levels. Many alterations and deviations from normal have been described in the literature. Some of these findings have been proposed as correlates for various conditions and pathological changes. However, relatively little of the vast amount of data acquired over the past decade or two will stand the test of close critical scrutiny as having a direct causal relationship to a particular manifestation of disease such as, for example, the precise variables which control the genesis of arteriosclerosis.
KeywordsDirect Causal Relationship Adequate Perfusion Electroviscous Effect Facet Area Fluid Mosaic Model
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