Viewpoint on Collagen Transition and Collagen as Temperature-Sensor
The human body functions at a temperature which is at the upper limit of the thermal stability of its molecular collagen. One reason for this must be that the processes of growth, repair and remodelling of tissues require a structural protein (such as collagen) not to be too stable. On the other hand the metabolic half-life of collagen is much greater than most other proteins, for in its protective and supportive role it has to be relatively permanent, while other more rapid turnover mechanisms are operating. There could be some risks in this state of affairs, as the following speculations suggest.
KeywordsMyocardial Damage Rheumatic Fever Supportive Role Collagen Disease Collagen Transition
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