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Viewpoint on Collagen Transition and Collagen as Temperature-Sensor

  • B. Rigby
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 62)

Abstract

The human body functions at a temperature which is at the upper limit of the thermal stability of its molecular collagen. One reason for this must be that the processes of growth, repair and remodelling of tissues require a structural protein (such as collagen) not to be too stable. On the other hand the metabolic half-life of collagen is much greater than most other proteins, for in its protective and supportive role it has to be relatively permanent, while other more rapid turnover mechanisms are operating. There could be some risks in this state of affairs, as the following speculations suggest.

Keywords

Myocardial Damage Rheumatic Fever Supportive Role Collagen Disease Collagen Transition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. BLIGH, J. (1973): Temperature Regulation in Mammals and Other Vertebrates, North-Holland, London.Google Scholar
  2. BORNSTEIN, P. (1980): The biosynthesis, secretion and processing of procollagen. In: Biology of Collagen A. Viidik and J. Vuust (eds). pp. 61–75. Academic Press, London.Google Scholar
  3. DINTENFASS, L., and RIGBY, B.J. (1976): Myocardial damage due to faulty heat exchange. Lancet 2: 93–94.CrossRefGoogle Scholar
  4. GLASSTONE, S., LAIDLER, K.J. and EYRING, H. (1941): “The Theory of Rate Processes”, Ch. IX. McGraw Hill, New York.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • B. Rigby

There are no affiliations available

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