Calcium in the Ischaemic Myocardium
Injured cardiac myocytes accumulate Ca2+. It does not seem to matter whether the injury is due to reperfusion after prolonged periods of normothermic ischaemia (Shen and Jennings 1972a,b., Nayler 1981), sustained hypoxia (Nayler et al, 1979), a naturally occurring cardiomyopathy, or the reintroduction of Ca2+ after only a few minute’s of Ca2+-free perfusion (Nayler and Grinwald 1982), the end result is the same — that is, the cells become overloaded with Ca2+. The primary aim of this paper is to establish why injured myocytes accumulate Ca2+, particularly during reperfusion after a prolonged period of ischaemia, and then to define the route by which this Ca2+ enters.
KeywordsSarcoplasmic Reticulum High Energy Phosphate Ischaemic Episode Slow Channel Myocardial Ischemic Injury
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