Abstract
It is generally thought that the most important aspect of tissue perfusion is the delivery of oxygen to the cell. However, that is probably not the case. Cell metabolites and their removal by capillary perfusion are probably more critical. Absence of removal of cell metabolites will probably cause injury or death of the cell before lack of oxygen will.
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BROCKMAN, S.K. and JUDE, J.R. (1960): The tolerance of the dog brain to total arrest of the circulation. Bull. John Hopkins Hosp. 106: 74.
CROWELL, J.W. and HOUSTON, B. (1961): Effect of acidity on blood coagulation. Am. J. Physiol. 201: 379–382.
GOLLAN, F. (1967): The Adequacy of Anemic and Hypoxemic Perfusion in Reversibility of Cellular Injury Due to Inadequate Perfusion. Charles Thomas, Springfield, Illinois.
HARDAWAY, R.M. (1967): Clinical Management of Shock. Charles Thomas, Springfield, Illinois.
HARDAWAY, R.M. (1980): Metabolic acidosis produced by vasopressors. Surg. Gyn & Obst 151: 203–204.
HARDAWAY, R.M., ELOVITZ, M.J., BREWSTER, W.R. and HOUCHIN, D.N. (1966): Clotting time of heparinized blood. Arch. Surg. 89: 701–705.
NEELY, W.A., TURNER, M.D. and HAINING, J.L. (1963): Survival after asanguineous total body perfusion. Surgery. 54: 244–249.
PACE, D.M., THOMASON, J.R. and VAN CAMP, W.A. (1962): Effects of oxygen on growth in several established cell lines. J. Nat. Cancer Inst. 28: 897.
WINTERSTEIN, H. (1917): Ueber Wiederbelebung bei Herzstillstand. Munch. Med. Wochenschr. 5: 153.
WOLFE, K.B. (1960): Effects of hypothermia on cerebral damage resulting cardiac arrest. Am. J. Cardiol. 6: 809.
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© 1983 Plenum Press, New York
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Hardaway, R.M. (1983). Metabolites in Shock. In: Dintenfass, L., Julian, D.G., Seaman, G.V.F. (eds) Heart Perfusion, Energetics, and Ischemia. NATO Advanced Science Institutes Series, vol 62. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0393-1_21
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DOI: https://doi.org/10.1007/978-1-4757-0393-1_21
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