Calcium and Erythrocyte Microrheology: Pharmacological Applications

  • J. F. Stoltz
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 62)


Apart from the control and regulation mechanisms of the cardiovascular system, blood’s rheological properties also play a fundamental part in maintaining a good tissue perfusion. Although for very many years these parameters were neglected, they are now fully recognized. Of these parameters, erythrocyte deformability is no doubt one of the most important determinants in understanding microcirculation and the corresponding tissue exchanges. In parallel with these physiological studies, some recent work has made it possible to define the biochemical mechanisms that combine to preserve erythrocyte deformability. The importance of calcium has already been mentioned. This work is aimed at anticipating an investigation into how calcium interferes with the microrheological properties of the erythrocyte, as well as into the influence of pharmacological agents known for their calcium antagonist properties.


Calcium Antagonist Erythrocyte Deformability Human Erythrocyte Membrane Internal Viscosity Erythrocyte Shape 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • J. F. Stoltz
    • 1
  1. 1.Groupe d’Hémorhéologie Centre de Transfusion Sanguine BraboisVandoeuvre - lés - NancyFrance

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