Blood Viscosity in Myocardial Infarction

  • J. Dormandy
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 62)


In recent years a large number of studies have focussed on the importance of blood rheology during and after acute myocardial infarction (MI). Regardless of the exact pathophysiological mechanism underlying the disease, MI probably results from an imbalance between the oxygen supply and oxygen demand of the myocardium. After the acute event, there is a phase of potentially reversible damage. Depending on the size of the ischaemic lesion, the surrounding marginal tissue may partly contribute to the perfusion of the lesion. During this stage, the ultimate size of necrosis may be determined and during this process haemorheological factors may be particularly relevant. Very much less is known about the role of abnormal haemor-heology at earlier stages in the disease process, that is at the initiation of acute occlusion by a thrombus or during the long term development of atherosclerosis. There is however some interesting evidence that haemorheological abnormalities may also be important at these earlier stages, which will be considered at the end.


Blood Viscosity Arterial Thrombosis Intermittent Claudication Plasma Fibrinogen Plasma Viscosity 
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  1. BARNES, A.J., LOCKE, P., SCUDDER, P.R., DORMandY, T.L., DORMandY, J.A. and SLACK, J. (1977): Is hyper viscosity a treatable component of diabetic microcirculatory disease? Lancet iii: 789–791.CrossRefGoogle Scholar
  2. BIRNBAUM, M. (1963): Normal hemoglobin level and coronary heart disease. Am. Heart. J. 65: 136.CrossRefGoogle Scholar
  3. BONDOLI, A., MARANA, E., MAGALINI, S., SABATO, A., and RANIERI, R. (1977): Changes in blood viscosity and plasma proteins in myocardial infarction. Resuscitation 5: 175.CrossRefGoogle Scholar
  4. BORN, G.V.R. (1978): Arterial thrombosis and its prevention. Proceedings of the World Congress of Cardiology, Tokyo, September, 1978. To be published by Elsevier, Amsterdam.Google Scholar
  5. BURCH, G. and DE PASQUALE, N. (1962): The hematocrit in patients with myocardial infarction. JAMA 180: 62.CrossRefGoogle Scholar
  6. BURGE, P.S., JOHNSON, W.J. and PRANKERD, T.A.J. (1975): Morbidity and mortality in pseudopolycythaemia. Lancet i: 1266–1269.CrossRefGoogle Scholar
  7. CHIEN, S. (1976): Clinical rheology in cardiovascular disease. Bibl. Anat. 16: 472.Google Scholar
  8. CHIEN, S. (1977): Blood Cells 3: 71.Google Scholar
  9. CHMIEL, H., EFFERT, S., and MATHEY, D. (1973): Rheologische Verànderungen des Blutes bein akuten. Herzinfarkt und dessen Risikofactoren. Dtsch Med Wschr 98: 1641.CrossRefGoogle Scholar
  10. DINTENFASS, L. (1969): Blood rheology in pathogenesis of the coronary heart diseases. Am. Heart J. 77: 139–147.CrossRefGoogle Scholar
  11. DINTENFASS, L. and FORBES, C. (1973): Viscosity of blood in patients with myocardial infarction, haemophilia and thyroid disease. Biorheology 10: 457–462.Google Scholar
  12. DINTENFASS, L. and FORBES, C.D. (1974): Viscosity of blood in patients with myocardial infarction. Hematologia 8: 523–533.Google Scholar
  13. DINTENFASS, L., JULIAN, D., and MILLER, G. (1966): Viscosity of blood in normal subjects and in patients suffering from coronary occlusion and arterial thrombosis. Am. Heart J. 71: 587–600.CrossRefGoogle Scholar
  14. DI PERRI, T. and FORCONI (1981): Communication at 2nd European Conference on Clinical Haemorheology, London.Google Scholar
  15. DITZEL, J. (1972): Hemodilution in myocardial infarction. In Hemodilution. Messmer, K., Schmid-Schubein, H. (Eds.), p. 264. Karger, Basel.Google Scholar
  16. DODDS, A., BOYD, M., ALLEN, J., BENNETT, E.D., FLUTE, P.T. and DORMandY J.A. (1980): Changes in red cell deformability and other haemorheological variables after myocardial infarction. Brit Heart J. 44: 508.CrossRefGoogle Scholar
  17. DORMandY, J.A. (1971): Influence of blood viscosity in blood flow and the effect of low molecular dextran. Brit. Med. J. iv: 716–719.CrossRefGoogle Scholar
  18. DORMandY, J.A., GOYLE, K.B., and REID, H.L. (1977): Treatment of severe intermittent claudication by controlled defibrination. Lancet i: 625–626.CrossRefGoogle Scholar
  19. DORMandY, J.A. (1978): Role of fibrinogen in peripheral circulatory diseases. International Conference on Atherosclerosis. Carlson LA, Ed. Raven Press, p. 409–416. New York.Google Scholar
  20. DORMandY, J., BOYD, M. and ERNST, E. (1981): Red cell filterability after myocardial infarction. Scan. J. Clin. Lab. Invest. 41: Suppl 156, 195.CrossRefGoogle Scholar
  21. EASTHAM, R.D. and MORGAN, E.H. (1963): Plasma fibrinogen levels in coronary artery disease. Lancet 2: 1196.CrossRefGoogle Scholar
  22. ERNST, E., MATRAI, A., DORMandY, J.A. and FLUTE, P.T. (1981): Is there a correlation between red cell filterability and blood viscosity measurements? Clinical Hemorheology 1: 335.Google Scholar
  23. FRY, D.L. (1968): Acute vascular endothelial changes associated with increased blood velocity gradients. Circ. Res. 22: 165–197.Google Scholar
  24. FULTON, R. and DUCKETT, K. (1976): Plasma fibrinogen and throm-bemboli after myocardial infarction. Lancet 22: 1161.CrossRefGoogle Scholar
  25. GILCHRIST, E., and TULLOCK, J. (1982): Observations on plasma fibrinogen content after myocardial infarction, Edin Med. J. 59: 561.Google Scholar
  26. GOLDSMITH, H.L. and KARINO, T. (1979): In: Quantitative Cardiovascular Studies. Hwang, N.H.C., Gross, D.R., Patel, D.J. eds. University Park Press, Baltimore.Google Scholar
  27. HARKNESS, J. and WHITTINGTON, R.B. (1971): The viscosity of human blood plasma: Its changes in disease and on the exhibition of drugs. Rheol. Acta 10: 55.CrossRefGoogle Scholar
  28. HARKNESS, J (1971): The viscosity of human blood plasma: its measurements in health and disease. Biorheology: 171.Google Scholar
  29. HERSCHBERG, P., WELLS, R., and GandY, R. (1972): Hematocrit and prognosis in patients with acute myocardial infarction. JAMA 219: 7.CrossRefGoogle Scholar
  30. ISOGAI, Y., ICHIBA, K., JIDA, A., CHIKATSU, I., and ABE, M. (1971): Viscosity of blood and plasma in various diseases. In Theoretical and Clinical Haemorheology, Hartert, H.H., Copley, A.L. eds: p. 326. Berlin, Springer, Verlog, Berlin.CrossRefGoogle Scholar
  31. JAN, K., CHIEN, S., and BIGGER, T. (1975): Observations on blood viscosity changes after acute myocardial infarction. Circulation 51: 1079.Google Scholar
  32. JOHNSSON, R. (1981): Annals of Clinical Research 13: N: 2, 77.Google Scholar
  33. JUHAN, I., BUONOCORE, M., JOUVE, R., VAGUE, P.H., MOULIN, J.P. and VIALETTES, B. (1982): Lancet i: 535–537.CrossRefGoogle Scholar
  34. KALLIO, V., SALMIVALLI, M. and BRUMMER, P. (1967): Blood viscosity changes in patients hospitalised because of acute chest pain. Cardiologia 50: 323.CrossRefGoogle Scholar
  35. KANNEL, W.B., GORDON, T., WOLF, P.A. and MCNAMARA, P. (1972): Haemoglobin and the risk of cerebral infarction: The Framingham study. Stroke 3: 409–420.CrossRefGoogle Scholar
  36. KELLOG, F., JOSEPH, R. and GOODMAN, P. (1969): Viscosity of blood in myocardial infarction. Circ. Res. 8: 972.Google Scholar
  37. LANGSJOEN, P. and INMON, T. (1967): Rheological changes in myocardial infarction. Am. Heart J. 73: 430.CrossRefGoogle Scholar
  38. LEONHARDT, H. and ARNTZ, H. (1977): Zusammenhange zwischen kardio-vascularen Risikofactoren und der Blutviscositat unter besonderer Beruksichtigung der Hyperlipoproteinamien. Rheol. Acta 16: 368.CrossRefGoogle Scholar
  39. LORIENT-ROUDANT, M., MANHAU, H., BRIVAUD, H. and BOISSEAU, M. (1981): Scand J. Clin. Lab. Invest. 41: Suppl 156: 203.CrossRefGoogle Scholar
  40. LOSNER, S. and VOLK, B. (1956): Fibrinogen concentrations in various clinical conditions. Am. J. Med. Sci, 232: 276.CrossRefGoogle Scholar
  41. LOWE, G.D.O., DRUMMOND, M.M., LORIMER, A.R., HUTTON, J., FORBES, C.D., PRENTICE, C.R.M., and BARBENEL, J.C. (1980): Relation between the extent of coronary artery disease and blood viscosity. Brit, Med. J. 280: 673.CrossRefGoogle Scholar
  42. MATRAI, A., BOGAR, L., and FENDLER, K. (1979): A hematokrit es a fibrinogenszint szerepe a ver rheologiai tulajdonsagainak megha-tarozasaban. Kis Orvostud 31: 204.Google Scholar
  43. MAYER, G. (1966): Blood viscosity in healthy subjects and patients with coronary heart disease. Can. Med. Ass. J. 91: 951.Google Scholar
  44. MEADE, T.W. (1979): Personal communication.Google Scholar
  45. PAYLING-WRIGHT, H. and BORN, G.V.R. (1971): Possible effect of blood flow on the turnover rate of vascular endothelial cells. In: Theoretical and Clinical Haemorheology. Hartert H, Copley AL, eds. Springer, Verlag, Berlin, Heidelberg.Google Scholar
  46. PEDERSEN, T. and PERSSON, J. (1967): The viscosity of the blood in coronary occlusion. Cardiologia 51: 283.CrossRefGoogle Scholar
  47. REID, H.L., DORMandY, J.A., BARNES, A.J., LOCKE, P.J. and DORMandY, T.L. (1976): Impaired red cell deformability in peripheral vascular disease. Lancet i: 666–667.CrossRefGoogle Scholar
  48. RODKIEWICZ, C.M. (1975): Localisation of early atherosclerotic lesions in the aortic arch in the light of fluid mechanics. J. Biomechanics 8: 149–156.CrossRefGoogle Scholar
  49. ROSENBLATT, G., STOKES, J. and BASSET, D. (1965): Whole blood viscosity hematocrit and serum lipid levels in normal subjects and patients with coronary heart disease. J. Lab. Clin. Med. 65: 202.Google Scholar
  50. ROZENBERG, M. (1968): Blood viscosity and thrombosis in vitro in patients with previous myocardial infarction. Angiology 19: 527.CrossRefGoogle Scholar
  51. SEDZIWY, L., THOMAS, M., and SHILLINGFORD, J. (1968): Some observations on hematocrit changes in patients with acute myocardial infarction. Br. Heart J. 30: 344.CrossRefGoogle Scholar
  52. THOMAS, D.J., MARSHALL, J., ROSS RUSSELL, R.W., WETHERLEY-MEIN, G. , DUBOULAY, G.H., PEARSON, T., SYMON, L. , and ZILKHA, E. (1977): Effect of haematocrit on cerebral blood flow in man. Lancet iv: 941–843.CrossRefGoogle Scholar
  53. VOLGER, E., OSTNER, K., KLEIN, J., and WIRTZFELD, A. (1979): Changes of red cell aggregation and deformability after acute myocardial infarction. Microsvasc. Res. 17: 153.Google Scholar
  54. YATES, C.J.P., BERENT, A., andREWS, V. and DORMandY, J.A. (1979): Increased leg blood flow by normovolaemic haemodilution in intermittent claudication. Lancet ii: 166–168.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • J. Dormandy
    • 1
  1. 1.St. George’s and St. James’ HospitalsLondonUK

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