Blood Viscosity in Myocardial Infarction

  • J. Dormandy
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 62)


In recent years a large number of studies have focussed on the importance of blood rheology during and after acute myocardial infarction (MI). Regardless of the exact pathophysiological mechanism underlying the disease, MI probably results from an imbalance between the oxygen supply and oxygen demand of the myocardium. After the acute event, there is a phase of potentially reversible damage. Depending on the size of the ischaemic lesion, the surrounding marginal tissue may partly contribute to the perfusion of the lesion. During this stage, the ultimate size of necrosis may be determined and during this process haemorheological factors may be particularly relevant. Very much less is known about the role of abnormal haemor-heology at earlier stages in the disease process, that is at the initiation of acute occlusion by a thrombus or during the long term development of atherosclerosis. There is however some interesting evidence that haemorheological abnormalities may also be important at these earlier stages, which will be considered at the end.


Blood Viscosity Arterial Thrombosis Intermittent Claudication Plasma Fibrinogen Plasma Viscosity 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • J. Dormandy
    • 1
  1. 1.St. George’s and St. James’ HospitalsLondonUK

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