Role of Platelets and Biophysical Factors in Thrombosis and Atherosclerosis

  • J. F. Stoltz
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 62)


Blood platelets play a fundamental part both in physiology, during hemostasis, and in pathology, in the initiation of thrombosis and the development of atherosclerosis. However, if the biochemical aspect of the mechanisms that lead to the formation of a platelet hemostatic plug have now been accurately determined, the biophysical and rheological factors involved have seldom been investigated although it is now admitted that they too participate in this process.


Shear Rate Platelet Aggregation Vascular Wall Blood Flow Velocity Platelet Adhesion 
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  1. ANDERSON, G.H., HELLUMS, J.D. , MOAKE, J., and ALFREY, C.P. (1978): Platelet response to shear stress : changes in serotonin uptake, serotonin release and ADP induced aggregation. Thrombosis Res. 13: 1039–1047.CrossRefGoogle Scholar
  2. ARFORS, K.E., and BERGQVIST, D. (1974): Influence of blood flow velocity experimental haemostasis plug formation. Thrombosis Res. 4: 447–461.CrossRefGoogle Scholar
  3. AURSNES, I., GJESDAL, K. and ABILDGOARD, U. (1981): Platelet aggregation induced by ADP from unsheared erythrocytes at physiological Ca++ — concentration. Brit. Haemat. 47: 149–152.CrossRefGoogle Scholar
  4. BAUMGARTNER, H.R. (1977): Platelet and fibrin deposition on subendo-thelium : opposite dependence on blood shear rate. In: International Congress on Thrombosis and Haemostasis — Philadelphia 1977. In: Thrombosis and Haemostasis, 38, 133 (abstract).Google Scholar
  5. BAUMGARTNER, H.R., and HAUDENSCHILD, L.A. (1972): Adhesion of platelets to subendothelium. Ann. N.Y. Acad. Sci., 201: 22–36.CrossRefGoogle Scholar
  6. BAUMGARTNER, H.R., MUGGLI, R., TSCHOPP, T.B., and TURITTO, V.T. (1976): Platelet adhesion, release and aggregation in flowing blood : effects of surface properties and platelet function. Thromb. Haemostasis, 35: 124–138.Google Scholar
  7. BEGENT, N., and BORN, G.V.R. (1970): Growth rate in vivo of platelet thrombi produced by iontophoresis of ADP as a function of mean blood flow velocity. Nature 227: 926–930.CrossRefGoogle Scholar
  8. BORN, G.V.R. (1976): Effects of unphysiological blood flow on circulating cells. Physiological and Clinical Aspects of Oxygenator Design, edited by S.G. Dawids and H.C. Engell Elsevier ed. 177–181.Google Scholar
  9. BORN, G.V.R. (1977): Fluid-mechanical and biochemical interaction in hemostasis. Brit. Med. Bull. 33: 193–197.Google Scholar
  10. BORN, G.V.R., and RICHARDSON, P.D. (1980): Activation time of blood platelets. J. Membrane Biol. 57: 87–90.CrossRefGoogle Scholar
  11. CASENAVE, J.P., BLONDOWSKA, D., RICHARDSON, M., KINLOUGH-RATHBONE, R.L., PACKHAM, M.A., and MUSTARD, J.F. (1979): Quantitative radioisotopic measurement and scanning electron microscopic study of platelet adherence to a collagen-coated surface and to subendothelium with a rotating probe device. J. Lab. Clin. Med. 93: 60–70.Google Scholar
  12. COLANTUONI, G., HELLUMS, J.D., MOAKE, J.L., and ALFREY, C.P. (1977): The response of human platelets to shear stress at short exposure time. Trans. Am. Soc. Artif. Organs 23: 626–630.CrossRefGoogle Scholar
  13. DEWITZ, T.S., MARTIN, R.R., SOLIS, R.T., HELLUMS, J.D., and MCINTIRE L.V. (1978): Microaggregate formation in whole blood exposed to shear stress. Microvas. Res. 26: 263–271.CrossRefGoogle Scholar
  14. DINTENFASS, L., and ROZENBERG, M.C. (1965): The influence of the velocity gradient on in vitro blood coagulation and artificial thrombosis. J. Atheroscler. Res. 5: 276–290.CrossRefGoogle Scholar
  15. DINTENFASS, L., and BAUER, G.E. (1970): Dynamic blood coagulation and viscosity and degradation of artificial thrombi in patients with hypertension. Cardiovasc. Res. 4: 50–60.CrossRefGoogle Scholar
  16. DOSNE, A.M., MICHEL, H. , MERVILLE, C., DROUET, L. , BODEVIN, E. , and CAEN, J.P. (1976): Interactions des plaquettes avec le sous-endothélium artériel. Groupe français d’étude sur l’hémostase et la thrombose, Toulouse, 6 mars 1976. Nouvelle Revue Française d’Hématologie 16: 273.Google Scholar
  17. FRIEDMAN, L.I., and LEONARD, E.E. (1971): Platelet adhesion to artificial surfaces : consequences of flows, exposure time, blood condition and surface nature. Federation Proceedings 30: 1641–1646.Google Scholar
  18. HARDWICK, R.A., HELLUMS, J.D., MOAKE, J.L., PETERSON, D.M., and ALFREY, C.P. (1980): Effects of antiplatelet agents onGoogle Scholar
  19. GLOVER, C.J., MCINTIRE, L.V. , LEVERETT, L.B., HELLUMS, J.D., BROWN, C.H., and NATELSON, E.A. (1974): Effect of shear stress on clot structure formation. Trans. Am, Soc. Artif. Int. Organs 20: 463:468.Google Scholar
  20. GLOVER, C.J., MCINTIRE, L.V., BROWN III C.H., and NATELSON, E.A. (1977): Mechanical trauma effect on clot structure formation. Thrombosis Res. 10: 11–25.CrossRefGoogle Scholar
  21. GOLDSMITH, T.H. (1974): Blood flow and thrombosis. Thrombosis et diathesis Haemorrhagica 32: 35–48.Google Scholar
  22. LARCAN, A., STOLTZ, J.F., and LEFORT, M. (1976): Facteurs biophysiques de la thrombose. La Revue de Médecine 17: 1343–1357.Google Scholar
  23. LEONARD, E.F. (1972): The role of flow in thrombogenesis. Bull. N.Y. Acad. Med. 48: 273–280.Google Scholar
  24. MCINTIRE, L.V., JUNTAMUKKULA, M.S., MOAKE, J.L., and PETERSEN, D.M. (1978): The use of rheological techniques to evaluate platelet function. Alterations caused by drug therapy. In: Biorheology Huang, C.H., and Copley, A.L. (Eds.). Aiche Symposium series 182: 74–80.Google Scholar
  25. MAJERUS, P.W., and MILETICH, J.P. (1978): Relationship between platelets and coagulation factors in hemostasis. Ann. Rev. Med. 29: 41–49.CrossRefGoogle Scholar
  26. MARMUR, A., and RUCKENSTEIN, E., (1980): Physico-chemical aspects of platelet adhesion and thrombogenesis. In : Advances in biomedical engineering — ch.7. D.O. Cooney (Ed.). Marcel Dekker inc (N.Y. — Basel) Part II: 341–390.Google Scholar
  27. MUSTARD, J.F., and PACKHAM, M.A., (1970): Factors influencing platelet function : adhesion, release, and aggregation. Pharmacol. Rev. 22: 97–187.Google Scholar
  28. MUSTARD, J.F., (1976): Function of blood platelets and their role in thrombosis. Trans. Amer. Clin. Climatol. Ass. 87: 104–127.Google Scholar
  29. NATHAN, G., FLEISHER, A., DVILANSKY, A., LIVNE, A., and PAROLA, A.H. (1980): Membrane dynamic alterations associated with activation of human platelets by thrombin. Biochemica et Biophysica 598: 417–421.CrossRefGoogle Scholar
  30. PACKHAM, M.A., GUCCIONE, M.A., GREENBERG, J.P., KINLOUGH-RATHBONE, R.L., and MUSTARD, J.F. (1977): Release of 14C-serotonin during initial platelet changes induced by thrombin, collagen, or A 23187. Blood 50: 915–926.Google Scholar
  31. RICHARDSON, P.D. (1973): Effect of blood flow velocity on growth rate of platelet thrombi. Nature 245: 103–104.CrossRefGoogle Scholar
  32. SCHMID-SCHONBEIN, H., and RIEGER, H. (1980): Platelet activation by shear forces : on the influence of flow conditions and platelet properties on platelet behaviour. Proceeding of the fifth international congress on thromboembolism — Bologna 1978. S. Coccheri (Ed.). Quaderni Delia Coagulazione pp 104–111.Google Scholar
  33. SCHMID-SCHONBEIN, H. , BORN, G.V.R., RICHARDSON, P.D., CUSAK, N., RIEGER, H., FORST, R., ROHLING-WINKEL, I., LASBERG, P., and WEHMEYER, A. (1981): Rheology of thrombotic processes in flow : the interaction of erythrocytes and thrombocytes subjected to high flow forces. Biorheology 18: 415–444.Google Scholar
  34. SHIGA, T., MAEDA, N., SUDA, T., KON, K., and SEKITA, M. (1980): Rheological and functional impairments in cholesterol loaded human erythrocytes. Experientia 36: 127–128.CrossRefGoogle Scholar
  35. STEVEN, D.E., JOIST, J.H., and SUTERA, S.P. (1980). Role of platelet-prostaglandin synthesis is shear induced platelet alterations. Blood 56: 753–758.Google Scholar
  36. STOLTZ, J.F. (1979): Biophysical factors of thrombosis. VII Int. Cong. Thromb. Haem. Londres, Juillet 1979, Thrombosis and Haemostasis 42: 347.Google Scholar
  37. STOLTZ, J.F. (1981): Are there hemorheological reasons for using drugs acting on platelets? Second Conference on Clinical Hemorheology London Sept-October 1981 (Abstract p. 109).Google Scholar
  38. STOLTZ, J.F. (1981): Ionized or ionizable groups of blood cells. In: The rheology of blood, blood vessels and associated tissues, ch 9. Gross, D.R. and Hwang, (Eds.). N.M.C. — Nato Advanced Study Institutes Series. Sijthoff and Noordhoff (Netherlands) Series E. Applied Sciences, 41: 184–213.Google Scholar
  39. STOLTZ, J.F., SOLAGNA, S. , VERRY, M., NICHOLAS, A., and DONNER, M. (1982): Approche physico-chimique de la cinétique d’adsorption de la ticlopidine sur la membrane des plaquettes sanguines humaines. J. des Maladies Vasculaires, 7: 125–128.Google Scholar
  40. STOLTZ, J.F., and VOISIN, P.H. (1982): Thrombotic processes and shear activation of platelets : pharmacological approaches. Clinical Hemorheology, 2: (in press).Google Scholar
  41. SUTERA, S.P. (1977): Flow induced trauma to blood cells. Circ. Res. 41: 2–8.Google Scholar
  42. VOISIN, PH., LARCAN, A., and STOLTZ, J.F. (1982): Activation rhéologique des plaquettes sanguines : étude préliminaire. J. Mal. Vasc, (in press).Google Scholar
  43. WILLIAMS, A.R. (1979): The induction of intravascular thrombi in vivo by means of localised hydrodynamic shear stresses. Basic Aspects of Blood Trauma pp. 63–73.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • J. F. Stoltz
    • 1
  1. 1.Groupe d’hémorhéologieCentre Régional de TransfusionVandouevre-les-NancyFrance

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