Pharmacological Approach to Perfusion

  • G. A. Marcel
  • L. George
  • D. Weill
  • E. Catry
  • Y. Hoffman
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 62)


According to Webster’s dictionary, perfusion is “the pumping of blood through tissues and organs”. The “pumping” will not be discussed in this paper, but only certain hemorheological aspects that the authors are familiar with. The red cell, as it is the vector of oxygen, is by far the most important factor of perfusion. The topic can therefore be divided into two main chapters at which pharmacology can be aimed: “Extra-erythrocytic factors of perfusion” and erythrocytic factors of perfusion”.


Sickle Cell Disease Sickle Cell Mean Corpuscular Volume Pharmacological Approach Sickle Erythrocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. ARNESEN, H., HOISETH, A. and LY, B. (1982): Streptokinase or heparin in the treatment of deep vein thrombosis. Follow-up results of a prospective trial. Acta, Med. Scand. 211: 65–68.CrossRefGoogle Scholar
  2. BESSIS, M., and MOHANDAS, N. (1974): Mesure Continue de la Déformabilité Cellulaire par une Méthode Diffractomëtrique. C.R. Acad. Sci. (Paris) 278: 3263–3265.Google Scholar
  3. BREWER, G.J. (1974): General Red Cell Metabolism In: “The Red Blood Cell” (D. Mac N. Surgenor ed.). Academic Press, 387–433.Google Scholar
  4. BRIEHL, R.W. (1981): Physical Chemical Properties of Sickle Cell Hemoglobin. In: The Function of Red Blood Cells. (D.H.F. Wallach ed). Alan Riss, Inc., New York. 241–278.Google Scholar
  5. CHESNEY, C.M., PIFER, D.D., BYERS, L.W., and MUIRHEAD, E.E. (1982): Effect of platelet activating factor on human platelets. Blood. 59: 582–585.Google Scholar
  6. CHIEN, S. (1970): Shear dependence of effective cell volume as a determinant of blood viscosity. Science 168: 977–979.CrossRefGoogle Scholar
  7. CHIEN, S. (1981): Final summary of the international symposium on filterability and red blood cell deformability. Scand J. Clin. Lab. Invest 41: suppl. 156: 213–216.Google Scholar
  8. DAVIES, J.A., MERRICK, M.V., SHARP, A.A. and HOLT, J.M. (1972): Controlled trial of ancrod and heparin in treatment of deep vein thrombosis of lower-limb. Lancet 1: 113–118.CrossRefGoogle Scholar
  9. DESNOYERS, P.C. (1978): Indirect fibrinolytic agents. In: Fibrinolytics and Antifibrinolytics F. Markwardt (ed). Springer-Verlag, Berlin, Heidelberg: 273–314.Google Scholar
  10. DESNOYERS, P., ANSTETT, M., LABAUME, J. and SCHMITT, H. (1974): Effect of and adrenoreceptor stimulating and blocking agents on fibrinolytic activity in rates. In “Second Int. Conf. on Synthetic Fibrinolytic — Thrombolytic Agents” Paris, Sept. 1974.Google Scholar
  11. DEYKIN, D. (1982): Current status of anticoagulant therapy. Am. J. Med. 72: 659–664.CrossRefGoogle Scholar
  12. DZANDU, J.K. and JOHNSON, R.M. (1980): Membrane protein phorphorylation in intact normal and sickle cell erythrocytes. J. Biol. Chem. 255: 6382–6386.Google Scholar
  13. European Cooperative Study Group for Streptokinase Treatment in Acute Myocardial Infarction. (1979): New Engl. J. Med. 301: 797–802.CrossRefGoogle Scholar
  14. GREGERSEN, M.I., BRYANT, C.A., HAMMERLE, W.E., USAMI, S., and CHIEN, S. (1967): Flow characteristics of human erythrocytes through polycarbonate sieves. Science 157: 825–827.CrossRefGoogle Scholar
  15. GÜEGUEN, M., DELAMAIRE, D.D., RISS, F., DARCET, PH., GODINOT, B., GENETET, B. and BOUREL, M. (1982): Perturbations hémorhéo-logiques et composition lipidique membranaire au cours des hépatites alcooliques. In: “7éme Réunion du Groupe Français de Filtration Erythrocytaire”. 4–5 juin 1982 — Hoechst Ed. p. 28.Google Scholar
  16. HEBBEL, R.P., YAMADA, O., MOLDOW, Ch.F., JACOB, H.S., WHITE, J.G. and EATON, J.W. (1980): Abnormal adherence of sickle erythrocytes to cultured vascular endothelium. J. Clin. Invest. 65: 154–160.CrossRefGoogle Scholar
  17. HEBBEL, R.P., STEINBERG, M.H. and EATON, J.W. (1981): Erythrocyte calcium abnormalities in sickle cell disease. In: The Function of Red Blood Cells. (D.F.H. Wallach ed). Alan R. Liss, Inc., New-York: 321–332.Google Scholar
  18. HERRMANN, T., VASSELON, C., GEYSSANT, A. and HEALY, J.C. (1981): Red blood cell filterability, oxygen saturation, ATP intracellular stock, and cerebral microcirculation. Scand. J. Clin. Lab. Invest. 41 (Suppl. 156): 213–216.CrossRefGoogle Scholar
  19. HIRSCH, J. (1981): Selection and results of antiplatelet therapy in the prevention of stroke and myocardial infarction. Arch. Int. Med. 141: 311–315.CrossRefGoogle Scholar
  20. HULL, R.B., DELMORE, T., GENTON, E., et al.(1979): Warfarin sodium versus low-dose heparin in the long-term treatment of venous thrombosis. N. Engl. J. Med. 301: 855–858.CrossRefGoogle Scholar
  21. International Multicenter Trial. Prevention of fatal postoperative pulmonary embolism by low doses of heparin (1975). Lancet. II: 45–51.Google Scholar
  22. KENNY, M.W., MEAKIN, M., and STUART, J. (1981): Measurements of erythrocyte filterability using washed-erythrocyte and whole-blood methods. Clin. Hemorheol. 1: 135–146.Google Scholar
  23. KIESEWETTER, H., DAUER, U., GESCH, M., SEIFFGE, D., ANGELKORT, B. and SCHMID-SCHONBEIN, H. (1981): A method for the measurement of the red blood cell deformability. Scand. J. Clin. Lab. Invest. 41 (suppl. 156): 229–232.CrossRefGoogle Scholar
  24. KONTOS, H.A., ENOCH, P.W., RAPER, A.J. and PATTERSON, J.L. (1971): Role of hypercapnic acidosis in the local regulation of blood flow in muscle. Circ. Res. suppl I to vol 28 and 29: 98–105.Google Scholar
  25. KONTOS, H.A., ENOCH, P.W., RAPER, A.J. and PATTERSON, J.L. (1977): Local mechanisms of C02 action on cat pial arterioles. Stroke. 8: 226–229.CrossRefGoogle Scholar
  26. KOUTSOURIS, D.D., (1982): Etudes de facteurs physico-chimiques de la déformabilité erythrocytaire. Thése de doctorat de 3éme cycle — Université de Parish XIII.Google Scholar
  27. LA CELLE, P.L. and WEED, R.I. (1970): Low oxygen pressure: a cause of erthrocyte membrane rigidity; J. Clin. Invest. 49: 54A–55A.Google Scholar
  28. LAGRUE, G., MARCEL, G.A., FAUCHER, G., GALLAIS, M. and BRANELLEC, A. (1979): Déformabilité érythrocytaire: influence du tabagisme et des facteurs de risque vasculaire. Nouv. Pres. Med. 8: 4079–4081.Google Scholar
  29. LEBLOND, P.F. and COULOMBE, L. (1979): The measurements of erythrocyte deformability using micropore membranes, A sensitive technique with clinical applications, J. Lab. Clin. Med. 94: 133–143.Google Scholar
  30. LECOMTE, M.C. and BOIVIN, P. (1981): Effect of Methylxanthine derivatives on red cell phosphorylation. Scand. J. Clin. Lab. Invest. 41 (suppl. 156): 291–295.CrossRefGoogle Scholar
  31. LESSIN, L.S., KURANTSIN-MILLS, J. and WEEMS, H.B. (1977): Deformability of normal and sickle erythrocytes in a pressure flow filtration system. Blood Cells. 3: 241–262.Google Scholar
  32. LOELIGER, E.A. (1979): Oral anticoagulation after myocardial infarction, in: Arterial Thromboembolism in Cardiovascular Diseases: The Therapeutics of Today. Verstraete, Dewar and Samama Eds. Scand. Journ. Haemat. 27 (Supp. 38): 87–95 (Munksgaard, Copenhagen 1981).Google Scholar
  33. LORAND, L., WEISSMAN, L.B., EPEL, D.L. and BRUNER-LORAND, J. (1976): Role of the intrinsic transglutaminase in the Ca++ mediated cross-linking of erythrocyte proteins. Proc. Nat. Acad. Sci. U.S.A. 73: 4479–4481.CrossRefGoogle Scholar
  34. MARCEL, G.A., CASPAR, C., SABATIER, C. and RAPIN, M. (1973, 1973a): Significance of kaolin-induced arginine esterase in human plasma during septic shock: depletion in prekallikrein and prekall-ikrein activator. Thromb. Res. 3: 281–294.CrossRefGoogle Scholar
  35. MARCEL, G.A., HABIB, R., CASPAR, C., SABATIER, C. and RAPIN, M. (1973, 1973b): Corticosteroid enhancement of renal vascular lesions due to endotoxin in rabbits. Pathol. et Biol. 21 (suppl.) 19–23.Google Scholar
  36. MARCEL, G.A., SABATIER, C., GALBRUN, M. and CASPAR, C. (1974): Etude des effets sur l’aggrégation plaquettaire de quatre solutés de remplissage à base de gélatines fluides. Nouv. Pres. Méd. 3: 2260.Google Scholar
  37. MARCEL, G.A., CASPAR, C., SABATIER, C., GAUTRAY, J. and SCHIRAR, A., (1975): High prekallikrein levels during pregnancy. Pathol. et Biol. 23 (suppl): 66–68.Google Scholar
  38. NALBADIAN, R.M., HENRY, R.L. and MURAYANA, M. (1978): Sickle cell disease: two new therapeutic strategies. Lancet II: 570–571.CrossRefGoogle Scholar
  39. NILSSON, I.M. (1975): Phenformin and ethyloestrenol in recurrent venous thrombosis. In: Progress in Chemical Fibrinolysis and Thrombolysis. Davidson, Samama and Desnoyers (Eds): Raven- New York. 1: 1–12.Google Scholar
  40. PICTET, A., and GAMS, A. (1909): Synthése de la Papavérine. C. Rend. Acad. Sci. 149: 210–212.Google Scholar
  41. REED, P.W. and LARDY, H.A. (1972): A 23 187: a divalent cation ionophore. J. Biol. Chem. 242: 6970–6977.Google Scholar
  42. REID, H.L., BARNES, A.J., LOCK, P.J., and DORMANDY, J.A. (1976a): A single method for measuring erythrocyte deformability. J. Clin. Pathol. 29: 855–858.CrossRefGoogle Scholar
  43. REID, H.L., DORMANDY, J.A., BARNES, A.J., LOCK, P.J. and DORMANDY, T.L. (1976b): Impaired red cell deformability in peripheral vascular disease. Lancet 1: 666–668.CrossRefGoogle Scholar
  44. SALZMAN, E.W., DEYKIN, D., SHAPIRO, R.M. and ROSENBERG, R. (1975): Management of heparin therapy. Control prospective trial. New Engl. J. Med. 292: 1046–1050.CrossRefGoogle Scholar
  45. SCHMID-SCHONBEIN, H., MESSMER, K. and RIEGER, H. (1981): Hemodilution and flow improvement. Karger. Bibliotheca Haematologica.Google Scholar
  46. SHAKLAI, N., RANNEY, H.M. and SHARMA, V. (1981): Interactions of hemoglobin S with the red cell membrane. In: The Function of Red Blood Cells. (D.H.F. Wallach, ed). pp. 1–16. Alan R. Liss, Inc. New-York.Google Scholar
  47. SHEETZ, M.P. and CASALY, J. (1981): Phosphate metabolite regulation of spectrin interactions. Scand. J. Clin. Lab. Invest. 41 (suppl. 156): 117–122.CrossRefGoogle Scholar
  48. SIRS, J.A. (1977): Effects of storage on the respiratory function and flexibility of red blood cells. Blood Cells. 3: 409–423.Google Scholar
  49. SKALAK, R. (1981): What is red cell deformability? In: Recent Developments in Microcirculation Research. (Davis and G.A. Marchel Eds.). Excerpta Medica, pp. 31–44.Google Scholar
  50. SWANK, R.L. (1968): The screen filtration pressure method in platelet research. Signficance and interpretation. Ser. Haemat. 1: 146–167.Google Scholar
  51. SZEKELY, P. (1964): Systemic embolism and anticoagulant prophylaxis in rheumatic heat disease. Br. Med. J. 1: 1209–1212.CrossRefGoogle Scholar
  52. Urokinase-Streptokinase Pulmonary embolism trial. USPET Phase 2 results. A cooperative study. JAMA (1974): 229: 1606–1613.CrossRefGoogle Scholar
  53. USAMI, S., CHIEN, S., and BERTLES, J.F. (1975): Deformability of sickle cells as studied by microsieving. J. Lab. Clin. Med. 86: 274–279Google Scholar
  54. WALLACH, D.F.J. (1981): Membrane and endoskeletal defects in Hb SS erythrocytes. In: The Function of Red Blood Cells D.H.D. Wallach (Ed), pp 333–353. Alan Liss Inc. New-York.Google Scholar
  55. WAUTIER, J.L., PATON, R.C., WAUTIER, M.P., PINTIGNY, D., ABADIE, E., PASSA, Ph. and CAEN, J. (1981): Increased adhesion of erythrocytes to endothelial cells in diabetes mellitus and its relation to vascular complications. New Engl. J. Med. 305: 237–242.CrossRefGoogle Scholar
  56. WEED, R.I., LA CELLE, P.L. and MERRILL, E.W. (1969): Metabolic dependance of red cell deformability. J. Clin. Invest. 48: 795–809.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • G. A. Marcel
    • 1
  • L. George
    • 1
  • D. Weill
    • 1
  • E. Catry
    • 1
  • Y. Hoffman
    • 1
  1. 1.Laboratoire d’ Hémorhéologie. Laboratoires HoechstParis La DefenseFrance

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