The Ca-Antagonist Nifedipine Reduces Purine Nucleoside and Oxypurine Release from Ischemic Heart
Nifedipine* is a blocker of slow Ca-channels1,2, which is presently used for the treatment of angina pectoris and hypertension. Nifedipine -like other Ca-antagonists- is thought to have an ATP-sparing effect, but the data available are conflicting3–5. We studied the effect of nifedipine on nucleotide metabolism in the isolated (ischemic) rat heart. We used release of adenosine (catabolites) as a sensitive indicator for adenine nucleotide breakdown6. Nifedipine decreased the release of adenosine, inosine and (hypo)-xanthine during ischemia and reperfusion.
KeywordsCoronary Flow Adenine Nucleotide Energy Charge Purine Nucleoside Dimethyl Ester
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