Abstract
Nifedipine* is a blocker of slow Ca-channels1,2, which is presently used for the treatment of angina pectoris and hypertension. Nifedipine -like other Ca-antagonists- is thought to have an ATP-sparing effect, but the data available are conflicting3–5. We studied the effect of nifedipine on nucleotide metabolism in the isolated (ischemic) rat heart. We used release of adenosine (catabolites) as a sensitive indicator for adenine nucleotide breakdown6. Nifedipine decreased the release of adenosine, inosine and (hypo)-xanthine during ischemia and reperfusion.
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© 1984 Springer Science+Business Media New York
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de Jong, J.W., Harmsen, E., de Tombe, P.P., Keijzer, E. (1984). The Ca-Antagonist Nifedipine Reduces Purine Nucleoside and Oxypurine Release from Ischemic Heart. In: De Bruyn, C.H.M.M., Simmonds, H.A., Müller, M.M. (eds) Purine Metabolism in Man-IV. Advances in Experimental Medicine and Biology, vol 165. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0390-0_93
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DOI: https://doi.org/10.1007/978-1-4757-0390-0_93
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