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Inosine Incorporation into Adenine- and Guanine Nucleotides in the Isolated Perfused Rat Heart is Stimulated After Ischemia

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Purine Metabolism in Man-IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 165))

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Abstract

During myocardial ischemia, ATP is broken down to the AMP-cata-bolites adenosine, inosine, (hypo)xanthine and uric acid. These apolar compounds can easily pass the cell membrane and enter the blood stream1. After reperfusion, energy charge and CrP are restored, but ATP levels remain low, because of purine loss2. To restore ATP levels, 3 main pathways exist: 1. adenosine phosphorylation, 2. inosine/hypoxanthine salvage, 3. de novo synthesis.

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References

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Author information

Authors and Affiliations

  1. Cardiochemical Laboratory, Thoraxcenter Erasmus University Rotterdam, Rotterdam, The Netherlands

    Eef Harmsen, Peter de Tombe, Peter Achterberg & Jan Willem de Jong

Authors
  1. Eef Harmsen
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  2. Peter de Tombe
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  3. Peter Achterberg
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  4. Jan Willem de Jong
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Editor information

Editors and Affiliations

  1. University of Nijmegen Faculty of Medicine, Nijmegen, The Netherlands

    Chris H. M. M. De Bruyn

  2. Guy’s Hospital Medical School, London, UK

    H. Anne Simmonds

  3. University of Vienna, Vienna, Austria

    Mathias M. Müller

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© 1984 Springer Science+Business Media New York

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Harmsen, E., de Tombe, P., Achterberg, P., de Jong, J.W. (1984). Inosine Incorporation into Adenine- and Guanine Nucleotides in the Isolated Perfused Rat Heart is Stimulated After Ischemia. In: De Bruyn, C.H.M.M., Simmonds, H.A., Müller, M.M. (eds) Purine Metabolism in Man-IV. Advances in Experimental Medicine and Biology, vol 165. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0390-0_92

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  • DOI: https://doi.org/10.1007/978-1-4757-0390-0_92

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0392-4

  • Online ISBN: 978-1-4757-0390-0

  • eBook Packages: Springer Book Archive

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