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Malignant Hyperthermia: Adenine Incorporation and Adenine Metabolism in Human Platelets, Influenced by Halothane

  • M. P. Verburg
  • C. A. van Bennekom
  • F. T. Oerlemans
  • C. H. M. M. De Bruyn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

Malignant hyperthermia (MH) is a pharmacogenetic disorder, elicited during general anaesthesia and carries a high mortality (1). MH is elicited in susceptible subjects by volatile anaesthetics like halothane, ether, enflurane and depolarizing muscle relaxants like succinylcholine(1). The inheritance of MH is autosomal dominant with incomplete penetrance and variable expression(1).

Keywords

High Performance Liquid Chromatography Platelet Rich Plasma Volatile Anaesthetic High Performance Liquid Chromatography Analysis Malignant Hyperthermia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    G.A. Gronert, Malignant hyperthermia, Anesthesiol., 53:395.Google Scholar
  2. 2.
    C.C. Solomons, S. Tan and J.A. Aldrete, Platelet metabolism and malignant hyperthermia, in:“Malignant Hyperthermia, 2nd International Symposium”, J.A. Aldrete and B.A. Britt, eds.; Grune and Stratton, New York (1978) p. 221.Google Scholar
  3. 3.
    C.C. Solomons, N. McDermott and M. Mahowald, Screening for malignant hyperthermia with a platelet bioassay, N. Eng. J. Med. 303:642 (letter to the editor) (1980).Google Scholar
  4. 4.
    J. Van Der Nat, Hyperpyrexia tijdens narcose (1968), Ned. T.v. Gen. 112, 2227 (1968).Google Scholar
  5. 5.
    F. Hoevenaars, R.C.A. Sengers, A.M. Stadhouders, M.J.M. Gielen, W.L.C. Brunings, J.M.F. Trijbels and H. Bookelman, Maligne hyperpyrexia: een vaak niet herkende complicatie van narcose. Ned. T. van Gen. 121, 976, (1977).Google Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • M. P. Verburg
    • 1
  • C. A. van Bennekom
    • 2
  • F. T. Oerlemans
    • 2
  • C. H. M. M. De Bruyn
    • 2
  1. 1.Dept. of AnaesthesiologyDe Wever HospitalHeerlenThe Netherlands
  2. 2.Dept. of Human GeneticsUniv. Hospital St. RadboudNijmegenThe Netherlands

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