Effect of Hypoxia and Exercise on Nucleotide Metabolism in Man
Intrapartum asphyxia affects about 1% of all newborn; the damage to the nervous system has been related to the excretion of hypoxanthine (Harkness et al., 1982). To interpret the changes found in pathological hypoxia we have studied the duration of hypoxanthine release after reducing muscle ATP by severe exercise in 7 adult males using similar conditions to those of Sutton et al. (1980). The concentrations of purine bases, nucleosides and nucleotides in plasma, urine, leucocytes and erythrocytes have been determined using the methods of Simmonds and Harkness (1981).
KeywordsAdenine Nucleotide Purine Metabolism Nucleotide Metabolism Severe Exercise Lesch Nyhan Syndrome
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