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Effect of Hypoxia and Exercise on Nucleotide Metabolism in Man

  • R. Angus Harkness
  • R. J. Simmonds
  • S. B. Coade
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

Intrapartum asphyxia affects about 1% of all newborn; the damage to the nervous system has been related to the excretion of hypoxanthine (Harkness et al., 1982). To interpret the changes found in pathological hypoxia we have studied the duration of hypoxanthine release after reducing muscle ATP by severe exercise in 7 adult males using similar conditions to those of Sutton et al. (1980). The concentrations of purine bases, nucleosides and nucleotides in plasma, urine, leucocytes and erythrocytes have been determined using the methods of Simmonds and Harkness (1981).

Keywords

Adenine Nucleotide Purine Metabolism Nucleotide Metabolism Severe Exercise Lesch Nyhan Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Harkness, R.A., Whitelaw, A.G.L., and Simmonds, R.J. 1982, Intrapartum hypoxia: the association between neurological assessment of damage and abnormal excretion of ATP metabolites, J. Clin. Path., in press.Google Scholar
  2. Schrader, J., Neas, S., and Gerlach, E., 1977, Evidence of a cell surface adenosine receptor on coronary myocytes and atrial muscle cells. Studies with an adenosine derivative of high molecular weight, Pfugers Archiv., 369: 251.CrossRefGoogle Scholar
  3. Simmonds, R.J., and Harkness, R.A., 1981, High performance liquid chromatographic methods for base and nucleoside analysis in extracellular fluids and in cells, J. Chromatogr., 226: 369.PubMedCrossRefGoogle Scholar
  4. Sutton, J.R., Toeurs, C.J., Ward, G.R., and Fox, I.H., 1980, Purine metabolism during strenuous muscular exercise in man, Metabolism, 29: 254.PubMedCrossRefGoogle Scholar
  5. Warnick, C.T., and Lazarus, H.M., 1981, Recovery of nucleotide levels after cell injury, Can. J. Biochem., 59: 116.PubMedGoogle Scholar
  6. Watts, R.W.E., Spellacy, E., Gibbs, D.A., Allsop, J., McKeran, R.O., Slavin, G.E., 1982, Clinical, postmortem, biochemical and therapeutic observations on the Lesch Nyhan syndrome with particular reference to the neurological manifestations, Quart. J. Med., 201: 43.Google Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • R. Angus Harkness
    • 1
  • R. J. Simmonds
    • 1
  • S. B. Coade
    • 1
  1. 1.Division of Perinatal MedicineMRC Clinical Research CentreHarrowUK

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