The Primary Structure and Posttranslational Modification of Human Hypoxanthine-Guanine Phosphoribosyltransferase
A complete deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) in man leads to the development of the Lesch-Nyhan syndrome (1) whereas a partial deficiency of the same enzyme leads to a severe form of gout (2). In an attempt to understand the molecular basis of these deficiency states, we have focused our recent studies on the structural and functional properties of HPRT from normal and enzyme-deficient patients.
KeywordsEdman Degradation Complete Amino Acid Sequence Citraconic Anhydride Human HPRT Staphylococcal Protease
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- 9.J.W. Wilson, G.E. Tarr, W.C. Mahoney, and W.N. Kelley, Human hypoxanithine-guanine phosphoribosyltransferase: complete amino acid sequence of the erythrocyte enzyme, J.Biol. Chem. in press (1982).Google Scholar