The Primary Structure and Posttranslational Modification of Human Hypoxanthine-Guanine Phosphoribosyltransferase

  • James M. Wilson
  • George E. Tarr
  • William N. Kelley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


A complete deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) in man leads to the development of the Lesch-Nyhan syndrome (1) whereas a partial deficiency of the same enzyme leads to a severe form of gout (2). In an attempt to understand the molecular basis of these deficiency states, we have focused our recent studies on the structural and functional properties of HPRT from normal and enzyme-deficient patients.


Edman Degradation Complete Amino Acid Sequence Citraconic Anhydride Human HPRT Staphylococcal Protease 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • James M. Wilson
    • 1
  • George E. Tarr
    • 1
  • William N. Kelley
    • 1
  1. 1.Departments of Internal Medicine and Biological ChemistryUniversity of Michigan Medical CenterAnn ArborUSA

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