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Cell-Cycle Dependent Variation in the Levels of Deoxyribonucleoside Triphosphate in Mouse T-Lymphoma Cells

  • Staffan Eriksson
  • Vince Groppi
  • Buddy Ullman
  • David W. MartinJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

De novo synthesis of deoxyribonucleotides occurs exclusively by the reduction of the corresponding ribonucleotides in a reaction catalyzed by the enzyme ribonucleotide reductase. The enzyme is subject to allosteric regulation in vitro and in vivo and its activity is closely correlated to the growth rate of cells. The changes in ribonucleotide reduction is correlated to changes in the measured deoxyribonucleoside triphosphate pools in a variety of cell lines but considerable variations in the relative levels of each of the four DNA precursors were found1.

Keywords

Ribonucleotide Reductase Thymidine Kinase Activity High Performance Liquid Chromato Deoxyribonucleoside Triphosphate Ribonucleoside Triphosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Staffan Eriksson
    • 1
  • Vince Groppi
    • 1
  • Buddy Ullman
    • 1
  • David W. MartinJr.
    • 1
  1. 1.Department of Medicine and Department of Biochemistry and BiophysicsUniversity of CaliforniaSan FranciscoUSA

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