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6-Mercaptopurine: Pharmacokinetics in Animals and Preliminary Results in Children

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Purine Metabolism in Man-IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 165))

Abstract

For three decades 6-mercaptopurine (6MP), an analog of hypoxan-thine, has been used in the treatment of acute lymphoblastic leukemia (ALL). Only in recent years sensitive and specific methods for the determination of 6MP and closely related drugs like 6-thioguanine (6TG) and azathioprine (AZA) have become available. The study of the pharmacokinetics of these drugs is possible now in animals and man, employing dose levels which are common in clinical practice.

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Author information

Authors and Affiliations

  1. Departments of Pediatrics (Div. Ped. Oncology), St. Radboud Hospital Catholic University, Nijmegen, The Netherlands

    T. J. Schouten, R. A. De Abreu, E. D. A. M. Schretlen & G. A. M. De Vaan

  2. Departments of Human Genetics, St. Radboud Hospital Catholic University, Nijmegen, The Netherlands

    C. H. M. M. De Bruyn

  3. Departments of Clinical Pharmacy, St. Radboud Hospital Catholic University, Nijmegen, The Netherlands

    E. Van Der Kleijn & M. J. M. Oosterbaan

Authors
  1. T. J. Schouten
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  2. R. A. De Abreu
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  3. C. H. M. M. De Bruyn
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  4. E. Van Der Kleijn
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  5. M. J. M. Oosterbaan
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  6. E. D. A. M. Schretlen
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  7. G. A. M. De Vaan
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Editor information

Editors and Affiliations

  1. University of Nijmegen Faculty of Medicine, Nijmegen, The Netherlands

    Chris H. M. M. De Bruyn

  2. Guy’s Hospital Medical School, London, UK

    H. Anne Simmonds

  3. University of Vienna, Vienna, Austria

    Mathias M. Müller

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© 1984 Springer Science+Business Media New York

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Schouten, T.J. et al. (1984). 6-Mercaptopurine: Pharmacokinetics in Animals and Preliminary Results in Children. In: De Bruyn, C.H.M.M., Simmonds, H.A., Müller, M.M. (eds) Purine Metabolism in Man-IV. Advances in Experimental Medicine and Biology, vol 165. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0390-0_69

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  • DOI: https://doi.org/10.1007/978-1-4757-0390-0_69

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0392-4

  • Online ISBN: 978-1-4757-0390-0

  • eBook Packages: Springer Book Archive

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