6-Mercaptopurine: Pharmacokinetics in Animals and Preliminary Results in Children
For three decades 6-mercaptopurine (6MP), an analog of hypoxan-thine, has been used in the treatment of acute lymphoblastic leukemia (ALL). Only in recent years sensitive and specific methods for the determination of 6MP and closely related drugs like 6-thioguanine (6TG) and azathioprine (AZA) have become available. The study of the pharmacokinetics of these drugs is possible now in animals and man, employing dose levels which are common in clinical practice.
KeywordsAcute Lymphoblastic Leukemia Maintenance Treatment Purine Nucleotide Prolonged Infusion Cytotoxic Reaction
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