Effects of 3-Deazaguanosine and 3-Deazaguanine on the Growth and Maturation of the Human Promyelocytic Leukemia Cell Line, HL-60
The purine analogues, 3-deazaguanosine (c3guo) and 3-deazaguanine (c3gua) have been found to inhibit the proliferation of various neoplastic cells in tissue culture and consequently are under investigation as potential anti-cancer drugs (1). Inhibition of cell growth by the deazapurines has been attributed to their effects on enzymes critical to normal purine metabolism. Although the metabolic effects of deazapurines are not fully understood, c3guo and c3gua have been reported to inhibit IMP dehydrogenase at millimolar concentrations (2).
KeywordsMycophenolic Acid Purine Metabolism Purine Nucleotide Purine Analogue Phosphoribosyl Transferase
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