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Effects of 3-Deazaguanosine and 3-Deazaguanine on the Growth and Maturation of the Human Promyelocytic Leukemia Cell Line, HL-60

  • Diane L. Lucas
  • Peter K. Chiang
  • Horace K. Webster
  • Roland K. Robins
  • William P. Wiesmann
  • Daniel G. Wright
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

The purine analogues, 3-deazaguanosine (c3guo) and 3-deazaguanine (c3gua) have been found to inhibit the proliferation of various neoplastic cells in tissue culture and consequently are under investigation as potential anti-cancer drugs (1). Inhibition of cell growth by the deazapurines has been attributed to their effects on enzymes critical to normal purine metabolism. Although the metabolic effects of deazapurines are not fully understood, c3guo and c3gua have been reported to inhibit IMP dehydrogenase at millimolar concentrations (2).

Keywords

Mycophenolic Acid Purine Metabolism Purine Nucleotide Purine Analogue Phosphoribosyl Transferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Diane L. Lucas
    • 1
  • Peter K. Chiang
    • 1
    • 2
  • Horace K. Webster
    • 1
  • Roland K. Robins
    • 1
    • 3
  • William P. Wiesmann
    • 1
  • Daniel G. Wright
    • 1
  1. 1.Dept. of HematologyWalter Reed Army Institute of ResearchUSA
  2. 2.Div. of BiochemistryWalter Reed Army Institute of ResearchUSA
  3. 3.Brigham Young UniversityProvoUSA

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