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Exploiting Biochemical Differences in Leukemia

  • Mary Sue Coleman
  • Michael R. Grever
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

Two enzymes, terminal deoxynucleotidyl transferase (TdT) and adenosine deaminase (ADA), play unique roles in DNA metabolism in the human immunological system. We have defined the relationship of these two enzymes to the disease course of chronic myelogenous leukemia and have established their utility as biological markers of disease activity.

Keywords

Chronic Lymphocytic Leukemia Chronic Myelogenous Leukemia Adenosine Deaminase Terminal Deoxynucleotidyl Transferase Mycosis Fungoides 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    M.S. Coleman and J.J. Hutton in D. Catovsky (ed) Methods in Hematology, Vol 2., Churchill Livingstone Press, 1981 pp. 203.Google Scholar
  2. 2.
    M.R. Grever, M.F. Siaw, W.F. Jacob, J.A. Neidhart, J.S. Miser, M.S. Coleman, J.J. Hutton and S.P. Balcerzak, Blood, 57, 406 (1981).PubMedGoogle Scholar
  3. 3.
    D.P. Gray, M.R. Grever, M.F. Siaw, M.S. Coleman and S.P. Balcerzak, Can. Treat. Rep., 66, 253 (1982).Google Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Mary Sue Coleman
    • 1
    • 2
  • Michael R. Grever
    • 1
    • 2
  1. 1.University of KentuckyLexingtonUSA
  2. 2.Ohio State UniversityColumbusUSA

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