Biochemical Basis for the Differential Effects of Deoxycoformycin on Human Leukemias
T-cell and null cell lines cultured in vitro are more sensitive to 2′-deoxycoformycin (DCF), an inhibitor of adenosine deaminase (ADA), plus 2′-deoxyadenosine (dAdo) than are B-cell lines1,2. The malignant, monoclonal cells of leukemia patients span a wide range of immunological types. This study compares the sensitivity of the various immunologic subtypes of leukemic cells to DCF plus dAdo and investigates the biochemical basis of the differential sensitivity. The information obtained may be of value in identifying the subtypes of leukemia that respond clinically to this drug.
KeywordsLeukemic Cell Thymidine Incorporation Adenosine Deaminase Biochemical Basis Null Cell
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- 1.R.M. Fox, S.K. Piddington, E.H. Tripp, M.H.N. Tattersall, Ecto-adenosine triphosphatase deficiency in cultured human T and null leukemic lymphocytes. J. Clin. Invest. 68:544, 1981.Google Scholar