5′-Methylthioadenosine Phosphorylase Deficiency in Malignant Cells: Recessive Expression of the Defective Phenotype in Intra-Species (Mouse X Mouse) Hybrids
In 1977, Toohey reported that some mouse cell lines lacked the recently described purine metabolic enzyme, 5′-methylthio-adenosine (MTA) Phosphorylase (5′-methylthioadenosine:orthophosphate methylthioribosyltransferase)(1). Subsequently, we found the same enzyme deficiency in seven out of thirty-one established human malignant cell lines. In contrast, none of sixteen cell lines of benign origin lacked the enzyme (2).
KeywordsL1210 Cell Hybrid Clone Polyamine Metabolism Hypoxanthine Phosphoribosyltransferase Scripps Clinic
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