5′-Methylthioadenosine Phosphorylase Deficiency in Malignant Cells: Recessive Expression of the Defective Phenotype in Intra-Species (Mouse X Mouse) Hybrids

  • Naoyuki Kamatani
  • Masaru Kubota
  • Erik H. Willis
  • Dennis A. Carson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


In 1977, Toohey reported that some mouse cell lines lacked the recently described purine metabolic enzyme, 5′-methylthio-adenosine (MTA) Phosphorylase (5′-methylthioadenosine:orthophosphate methylthioribosyltransferase)(1). Subsequently, we found the same enzyme deficiency in seven out of thirty-one established human malignant cell lines. In contrast, none of sixteen cell lines of benign origin lacked the enzyme (2).


L1210 Cell Hybrid Clone Polyamine Metabolism Hypoxanthine Phosphoribosyltransferase Scripps Clinic 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Naoyuki Kamatani
    • 1
  • Masaru Kubota
    • 1
  • Erik H. Willis
    • 1
  • Dennis A. Carson
    • 1
  1. 1.Department of Clinical ResearchScripps Clinic and Research FoundationLa JollaUSA

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