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Immunohistochemical Localization of Adenosine Deaminase in Human Lymphoid Tissues and Lymphomas

  • Boris Chechik
  • William Schrader
  • Ann Perets
  • Bernard Fernandes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

During the last decade, adenosine deaminase (ADA) has attracted a great deal of attention because of its involvement in the development of the immune system. In humans, deficiency of ADA is usually associated with a hereditary form of severe combined immunodeficiency (Giblett et al., 1972). The largest amounts of enzyme have been found in lymphoid tissues, particularly in the thymus gland (Adams et al., 1976) and leukemic lymphoblasts of thymic phenotype (Smith et al., 1978). Within the thymus, ADA is predominantly located in cortical thymocytes (Chechik et al., 1981), which express higher enzyme activity than do medullary and extrathymic lymphocytes (Barton et al., 1979). These findings led to the suggestion that ADA is associated with the intrathymic differentiation of T cells.

Keywords

Germinal Center Adenosine Deaminase Primary Follicle Small Lymphocytic Lymphoma Adenosine Deaminase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adams, A,, and Harkness, R.A., 1976, Adenosine deaminase activity in thymus and other human tissues, Clin. Exp. Immunol. 26: 647.PubMedGoogle Scholar
  2. Barton, R., Martiniuk, F., Hirschhorn, R., and Goldschneider, I., 1979, The distribution of adenosine deaminase among lymphocyte populations in the rat, J. Immunol. 122:216.PubMedGoogle Scholar
  3. Chechik, B.E., and Minowada, J., 1979, Quantitation of human thymus-leukemia-associated antigen in established hematopoietic cell lines by radioimmunoassay, J. Nat. Canc. Inst. 63:609.Google Scholar
  4. Chechik, B.E., Schrader, W.P., and Minowada, J., 1981, An immuno-morphologic study of adenosine deaminase distribution in human thymus tissue, normal lymphocytes, and hematopoietic cell lines, J. Immunol. 126:1003.PubMedGoogle Scholar
  5. Chechik, B.E., and SenGupta, S., 1981, Detection of human, rat and mouse adenosine deaminase by immunochemical and immunomorphologic methods using antiserum to calf enzyme, J. Immunol. Meth. 45:165.CrossRefGoogle Scholar
  6. Gelfand, E.W., Lee, J.J., and Dosch, H.M., 1979, Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function, Proc. Nat. Acad. Sci. USA, 76:1998.PubMedCrossRefGoogle Scholar
  7. Giblett, E.R., Anderson, J.E., Cohen, F., Pollara, B., and Meuwissen, H.J., 1972, Adenosine deaminase deficiency in two patients with severely impaired cellular immunity, Lancet 2: 1067.PubMedCrossRefGoogle Scholar
  8. Lukes, R.J., and Collins, R.D., 1974, Immunologie characterization of human malignant lymphomas, Cancer 34:1488.PubMedCrossRefGoogle Scholar
  9. Macdermott, R.P., Tritsch, G.L., and Formeister, J.F., 1980, Adenosine deaminase and nucleoside phosphorilase activity in normal human blood mononuclear cell subpopulations, Clin. Exp. Immunol. 42:303.PubMedGoogle Scholar
  10. Meuwissen, H.J., Pollara, B., and Pickering, R.J., 1975, Combined immunodeficiency disease associated with adenosine deaminase deficiency, J. Pediatr. 86:169.Google Scholar
  11. Smith, J.F., Poplack, D.G., Holiman, B.J., Leventhal, B.G., and Yarbro, G., 1978, Correlation of adenosine deaminase activity with cell surface markers in acute lymphoblastic leukemia, J. Clin. Invest. 62:710.Google Scholar
  12. Stein, H., Bonk, A., Tolksdorf, G., Lennert, K., Rodt, H., and Gerdes, J., 1980, Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin’s lymphomas, J. Histochem. Cytochem. 28:746.Google Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Boris Chechik
    • 1
    • 2
  • William Schrader
    • 1
    • 2
  • Ann Perets
    • 1
    • 2
  • Bernard Fernandes
    • 1
    • 2
  1. 1.Mount Sinai HospitalTorontoCanada
  2. 2.Kidney Disease InstituteAlbanyUSA

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