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Ecto-5′-Nucleotidase as a Leukemia Marker

  • Wolf Gutensohn
  • Eckhard Thiel
  • Silvia Buschette
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

In recent years an ever increasing set of cell surface and other markers has been used to classify and subclassify leukemic blast cells. Among these the socalled biochemical markers — mainly enzyme activities — have gained importance. One of these enzymes is terminal deoxynucleotidyl transferase but many enzymes of purine metabolism are also used (for a survey see Blatt et al1). 5′-Nucleotidase (5′-N) as an ectoenzyme has the double advantage of being testable by an ordinary enzyme assay on intact cells and at the same time being detectable by immunological methods as a surface structure. We have characterized leukemic cells using 5′-N not as an isolated marker but rather within a battery of other markers detectable by immunological means like specific antisera or rosetting assays.

Keywords

Chronic Lymphocytic Leukemia Acute Leukemia Chronic Myelogenous Leukemia Blast Crisis Immunological Marker 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    J. Blatt, G. Reaman and D.G. Poplack, Biochemical markers in lymphoid malignancy, New Engl.J.Med. 303: 918–922 (1980).PubMedCrossRefGoogle Scholar
  2. 2.
    R. Silber, M. Conklyn, G. Grusky and D. Zucker-Franklin, Human lymphocytes: 5′-Nucleotidase-positive and-negative subpopulations, J.Clin.Invest. 56: 1324–1327 (1975).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Wolf Gutensohn
    • 1
  • Eckhard Thiel
    • 1
  • Silvia Buschette
    • 1
  1. 1.Institut für Anthropologie und HumangenetikUniversität MünchenMünchen 2Fed. Rep. Germany

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