Purine and Pyrimidine Enzyme Markers in Human Lymphoid Malignancies
The pertinence to clinical practice of various classifications of human lymphoproliferative disease revolves around whether these arbitrary delineations of tumour properties are predictive either for disease behaviour or responsiveness to various therapeutic modalities and thus prognosis. In this regard the morphologic scheme for non Hodgkin’s lymphoma proposed by the modified Rappaport classification (1) and the utilization of cellular properties which denote the immunologic derivation of tumour cells (2) have both yielded useful frameworks which have clinical utility. To these assessments have recently been added cellular purine and pyrimidine enzymic profiles. These appear to complement the established markers for these disorders but more importantly may have potential therapeutic significance for the use of selective therapy such as adenosine deaminase and purine nucleoside Phosphorylase inhibition (3–5) or the in vivo use of nucleosides such as thymidine (6,7).
KeywordsChronic Lymphocytic Leukaemia Thymidine Kinase Adenosine Deaminase Thymidine Phosphorylase Purine Nucleoside Phosphorylase
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