Purine Metabolizing Enzyme Activities in Lymphoblastic Leukemia

  • J. P. R. M. van Laarhoven
  • G. Th. Spierenburg
  • G. C. de Gast
  • T. J. Schouten
  • C. H. M. M. De Bruyn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


Studies on patients with immunological dysfunctions have revealed that genetically determined deficiencies of certain enzymes of purine metabolism are intimately related to lymphocytic malfunction(1,2). This as a consequence of a differentiation and/or maturation block originating from the enzyme deficiencies (3). Since lymphoblastic leukemia may be considered as a disorder of lymphocyte differentiation and maturation (4), it is of interest to study systematically purine metabolism in lymphoid cells from patients with acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL).


Acute Lymphoblastic Leukemia Chronic Lymphocytic Leukemia Lymphoid Cell Chronic Lymphocytic Leukemia Patient Purine Metabolism 


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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • J. P. R. M. van Laarhoven
    • 1
  • G. Th. Spierenburg
    • 1
  • G. C. de Gast
    • 2
  • T. J. Schouten
    • 3
  • C. H. M. M. De Bruyn
    • 1
  1. 1.Dept. of Human GeneticsUniversity Hospital, University of NijmegenNijmegenThe Netherlands
  2. 2.Dept. of BloodtransfusionUniversity Hospital, University of UtrechtUtrechtThe Netherlands
  3. 3.Dept. of Pediatric OncologyUniversity Hospital, University of NijmegenNijmegenThe Netherlands

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