Purine Metabolizing Enzyme Activities in Lymphoblastic Leukemia

  • J. P. R. M. van Laarhoven
  • G. Th. Spierenburg
  • G. C. de Gast
  • T. J. Schouten
  • C. H. M. M. De Bruyn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


Studies on patients with immunological dysfunctions have revealed that genetically determined deficiencies of certain enzymes of purine metabolism are intimately related to lymphocytic malfunction(1,2). This as a consequence of a differentiation and/or maturation block originating from the enzyme deficiencies (3). Since lymphoblastic leukemia may be considered as a disorder of lymphocyte differentiation and maturation (4), it is of interest to study systematically purine metabolism in lymphoid cells from patients with acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL).


Acute Lymphoblastic Leukemia Chronic Lymphocytic Leukemia Lymphoid Cell Chronic Lymphocytic Leukemia Patient Purine Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    E.R. Giblett, J.E. Anderson, F. Cohen, B. Pollara and H.J. Meuwissen, Lancet ii:1067 (1972).CrossRefGoogle Scholar
  2. 2.
    E.R. Giblett, A.J. Ammann, D.W. Wara, R. Sandman and L.K. Diamond, Lancet i:1010 (1975).Google Scholar
  3. 3.
    L.F. Thompson and J.E. Seegmiller, Adv. Enzymol. 51: 167 (1980).PubMedGoogle Scholar
  4. 4.
    F. Gunz and A.G. Barke, “Leukemia”, Grune and Stratton, New York (1974).Google Scholar
  5. 5.
    E.M. Scholar and P. Calabresi, Cancer Res. 33: 94 (1973).PubMedGoogle Scholar
  6. 6.
    M.S. Coleman, M.F. Greenwood, J.J. Hutton, P. Holland, B. Lampkin, C. Krill and J.E. Kastelic, Blood 52: 1125 (1978).PubMedGoogle Scholar
  7. 7.
    J.F. Smyth, D.G. Poplack, B.J. Holiman, B.G. Leventhal and G. Yarbro, J. Clin. Invest. 62: 710 (1978).PubMedCrossRefGoogle Scholar
  8. 8.
    V. Liso, A. Tursi, G. Specchia, G. Grocolli, M.P. Loria and L. Bonomo, Scand. J. Haematol. 21: 167 (1978).PubMedCrossRefGoogle Scholar
  9. 9.
    H. Simpkins, A. Stanton and B.H. Davis, Cancer Res. 41: 3107 (1981).PubMedGoogle Scholar
  10. 10.
    J. Blatt, G.H. Reaman, N. Levin and D.G. Poplack, Blood 56: 380 (1980).PubMedGoogle Scholar
  11. 11.
    G.H. Reaman, N. Levin, A. Muchmore, B.J. Holiman and D.G. Poplack, New Engl. J. Med. 300: 1374 (1979).PubMedCrossRefGoogle Scholar
  12. 12.
    A.T. Huang, G.L. Logue and H.L. Engelbrecht, Brit. J. Haematol. 34: 631 (1976).CrossRefGoogle Scholar
  13. 13.
    B. Ramot, F. Brok-Simoni, N. Barnea, I. Bank and G. Holtzmann, Brit. J. Haematol. 36: 67 (1977).CrossRefGoogle Scholar
  14. 14.
    F. Ambrogi, B. Grassi, S. Ronca-Testoni and G. Ronca, Clin. Exp. Immunol. 28: 80 (1977).PubMedGoogle Scholar
  15. 15.
    M. Borgers, H. Verhaegen, M. de Brabander, J. de Cree, W. de Cock, F. Thoné and G. Geuens, Blood 52: 886 (1978).PubMedGoogle Scholar
  16. 16.
    J. Lopes, D. Zucker-Franklin and R. Silber, J. Clin. Invest. 52: 1297 (1973).PubMedCrossRefGoogle Scholar
  17. 17.
    J.A.J.M. Bakkeren, G.A.M. de Vaan and H.F.P. Hillen, Blood 53: 883 (1979).PubMedGoogle Scholar
  18. 18.
    W.E. Gathings, A.R. Lawton and M.D. Cooper, Eur. J. Immunol. 7: 804 (1977).PubMedCrossRefGoogle Scholar
  19. 19.
    J.C. Brouet, J.L. Preud’homme, C. Penit, F. Valensi, P. Rouget and M. Seligmann, Blood 54: 269 (1979).PubMedGoogle Scholar
  20. 20.
    S. Gupta, R. Pahwa, R. O’Reilly, R.A. Good and F.P. Siegal, Proc. Natl. Acad. Sci. U.S.A. 73: 919 (1976).PubMedCrossRefGoogle Scholar
  21. 21.
    J.P.R.M. van Laarhoven, G.Th. Spierenburg and C.H.M.M. de Bruyn, J. Immunol. Methods, 39: 47 (1980).PubMedCrossRefGoogle Scholar
  22. 22.
    R.A. De Abreu, J.M. van Baal, J.A.J.M. Bakkeren, C.H.M.M. de Bruyn and E.D.A.M. Schretlen, J. Chromatogr. 227: 45 (1982).PubMedCrossRefGoogle Scholar
  23. 23.
    D.A. Carson, J. Kaye and J.E. Seegmiller, J. Immunol. 121: 1726 (1978).PubMedGoogle Scholar
  24. 24.
    A. Cohen, J.W.W. Lee, H.M. Dosch and E.W. Gelfand, J. Immunol. 125: 1578 (1980).PubMedGoogle Scholar
  25. 25.
    H.J. Schuurman, J.P.R.M. van Laarhoven, R. Broekhuizen, P. Brekelmans, G.Th. Spierenburg, C.G. Figdor and C.H.M.M. de Bruyn, this volume.Google Scholar
  26. 26.
    J.E. Seegmiller, H. Bluestein, L. Thompson, R. Willis, S. Matsumoto and D. Carson, in:“Models for the Study of Inborn Errors of Metabolism”, F.A. Hommes, Ed., Elsevier/North-Holland Biomedical Press, Amsterdam, p.153 (1979).Google Scholar
  27. 27.
    F. Quagliata, D. Faig, M. Conklyn and R. Silber, Cancer Res. 34: 3197 (1974).PubMedGoogle Scholar
  28. 28.
    M. Rowe, G.C. de Gast, T.A.E. Platts-Mills, G.L. Asherson, A.D.B. Webster and S.M. Johnson, Clin. Exp. Immunol. 36: 97 (1979).PubMedGoogle Scholar
  29. 29.
    L.F. Thompson, G.R. Boss, H.L. Spiegelberg, T.C. Jansen, R.D. O’Connor, T.A. Waldmann, R.N. Hamburger and J.E. Seegmiller, J. Immunol. 123: 2475 (1979).PubMedGoogle Scholar
  30. 30.
    J.P.R.M. van Laarhoven, G.Th. Spierenburg, H. Collet, G. Delespesse and C.H.M. de Bruyn, this volumeGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • J. P. R. M. van Laarhoven
    • 1
  • G. Th. Spierenburg
    • 1
  • G. C. de Gast
    • 2
  • T. J. Schouten
    • 3
  • C. H. M. M. De Bruyn
    • 1
  1. 1.Dept. of Human GeneticsUniversity Hospital, University of NijmegenNijmegenThe Netherlands
  2. 2.Dept. of BloodtransfusionUniversity Hospital, University of UtrechtUtrechtThe Netherlands
  3. 3.Dept. of Pediatric OncologyUniversity Hospital, University of NijmegenNijmegenThe Netherlands

Personalised recommendations