Effect of Purine Nucleosides on Rat Macrophage Function
Deficiency of the purine degradation enzyme, purine nucleoside Phosphorylase (PNP), in humans, is associated with T-lymphocyte abnormalities and a marked reduction in T-lymphocyte numbers (1). In addition, these patients have a propensity to develop autoimmune disease (2). Deoxyguanosine, a PNP substrate which accumulates in PNP deficient humans (3), has been shown to interfere with the expression of suppressor cell activity in humans and in rodents (4–6). We have also shown that human thymocytes are exquisitely sensitive to the PNP substrate, deoxyguanosine, and have attempted to relate this to their stage of maturation (7).
KeywordsPeritoneal Macrophage Proliferative Response Purine Nucleoside Purine Nucleoside Phosphorylase Suppressor Cell Activity
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