Increased Incidence of Homogeneous Immunoglobulins in Irradiated, Reconstituted Mice After Prolonged Treatment with 2′-Deoxyguanosine
A homogeneous immunoglobulin component (H-Ig) is the result of excessive immunoglobulin (Ig) production by one of the B cell clones. H-Ig of the transient type appear in the serum of experimental animals after lethal irradiation and reconstitution (1). According to Rozing and Benner (2) the B cell compartment is fully developed about one month and the T cell compartment about 6 months after irradiation and reconstitution. The delayed recovery of T cells might facilitate uncontrolled clonal expansion of B cells (3). Involvement of only a few antigen-reactive B cell clones in an antibody response will be manifested in a restricted heterogeneity of the serum Ig spectrum. Dominance of a single B cell clone can lead to excessive production of a particular Ig, which after serum electrophoresis occurs as a narrow band (H-Ig) in the γ-globulin region.
KeywordsCell Clone Balance Salt Solution Foetal Liver Lethal Irradiation Serum Electrophoresis
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