Biochemical and Immunological Evaluation of Long Term Coformycin Administration in the Mouse

  • Trevor Lukey
  • Floyd F. Snyder
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


The inherited human deficiency of adenosine deaminase is associated with severe combined immunodeficiency disease1,2. Coformycin is a potent inhibitor of adenosine deaminase and markedly potentiates the in vitro toxicity of adenosine and deoxyadenosine toward lymphoid cells. We wished to evaluate some of the biochemical and immunological events associated with coformycin administration in vivo. Increased dATP concentrations observed in adenosine deaminase deficiency3 are thought to inhibit ribonucleotide reductase and thereby restrict DNA synthesis. Another secondary consequence of a deficiency of adenosine deaminase may be inhibition of S-adenosylhomocysteine hydrolase by de oxyadenosine4.


Adenosine Deaminase Severe Combine Immunodeficiency Severe Combine Immunodeficiency Disease Swiss Webster Mouse Pokeweed Mitogen 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Trevor Lukey
    • 1
  • Floyd F. Snyder
    • 1
  1. 1.Departments of Paediatrics and Medical Biochemistry Faculty of MedicineUniversity of CalgaryCalgaryCanada

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