Inhibition of Murine Suppressor T Cell Development by 2′-Deoxyguanosine in Vivo

  • Th. W. van den Akker
  • A. T. J. Bianchi
  • H. Bril
  • R. Benner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


Antigen-induced human suppressor T cell activity can be abrogated by micromolar concentrations of 2′-deoxyguanosine (dGuo) in vitro (1). In contrast, non-proliferative helper T cell activity and the differentiation and proliferation of the precursor B lymphocytes into IgM-producing antibody-forming cells have a more than 1,000-fold higher resistance to dGuo. The in vivo development of murine suppressor T cells involved in antibody formation can also be inhibited by dGuo (2). We investigated the effect of dGuo treatment upon the antigen-induced suppressor T cell activity, which normally arises in mice after intravenous (iv) administration of irradiated allogeneic cells (3).


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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Th. W. van den Akker
    • 1
  • A. T. J. Bianchi
    • 1
  • H. Bril
    • 1
  • R. Benner
    • 1
  1. 1.Department of Cell Biology and GeneticsErasmus UniversityDR RotterdamThe Netherlands

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