Inhibition of Murine Suppressor T Cell Development by 2′-Deoxyguanosine in Vivo
Antigen-induced human suppressor T cell activity can be abrogated by micromolar concentrations of 2′-deoxyguanosine (dGuo) in vitro (1). In contrast, non-proliferative helper T cell activity and the differentiation and proliferation of the precursor B lymphocytes into IgM-producing antibody-forming cells have a more than 1,000-fold higher resistance to dGuo. The in vivo development of murine suppressor T cells involved in antibody formation can also be inhibited by dGuo (2). We investigated the effect of dGuo treatment upon the antigen-induced suppressor T cell activity, which normally arises in mice after intravenous (iv) administration of irradiated allogeneic cells (3).
KeywordsSpleen Cell Balance Salt Solution Delay Type Hypersensitivity Specific Increase Donor Mouse
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- 6.H. Bril and R. Benner, Adv. Exp. Med. Biol., in press.Google Scholar