Regulation of Human Lymphoblast Ecto-5′-Nucleotidase by Zinc
Ecto-5′-nucleotidase (5′NT) catalyzes the degradation of purine nucleotide-5′-monophosphates to nucleosides and inorganic phosphate; it is an integral plasma membrane enzyme of most mammalian cells and widely used as a membrane marker. Although the physiological role of 5′NT is still mostly obscure, decreased 5′NT activity was found to be associated with a variety of immunological disorders and lymphoproliferative diseases (1–6). 5′NT was suggested to provide a marker for B- and T-lymphocyte maturation (5,7).
KeywordsChronic Lymphocytic Leukemia Zinc Deficiency Infectious Mononucleosis Nucleotidase Activity Zinc Metabolism
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