Regulation of Human Lymphoblast Ecto-5′-Nucleotidase by Zinc

  • R. B. Pilz
  • R. C. Willis
  • S. Wanlass
  • J. E. Seegmiller
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


Ecto-5′-nucleotidase (5′NT) catalyzes the degradation of purine nucleotide-5′-monophosphates to nucleosides and inorganic phosphate; it is an integral plasma membrane enzyme of most mammalian cells and widely used as a membrane marker. Although the physiological role of 5′NT is still mostly obscure, decreased 5′NT activity was found to be associated with a variety of immunological disorders and lymphoproliferative diseases (1–6). 5′NT was suggested to provide a marker for B- and T-lymphocyte maturation (5,7).


Chronic Lymphocytic Leukemia Zinc Deficiency Infectious Mononucleosis Nucleotidase Activity Zinc Metabolism 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • R. B. Pilz
    • 1
  • R. C. Willis
    • 1
  • S. Wanlass
    • 1
  • J. E. Seegmiller
    • 1
  1. 1.Dept. of MedicineUniversity of California San DiegoLa JollaUSA

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