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Regulation of Human Lymphoblast Ecto-5′-Nucleotidase by Zinc

  • R. B. Pilz
  • R. C. Willis
  • S. Wanlass
  • J. E. Seegmiller
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

Ecto-5′-nucleotidase (5′NT) catalyzes the degradation of purine nucleotide-5′-monophosphates to nucleosides and inorganic phosphate; it is an integral plasma membrane enzyme of most mammalian cells and widely used as a membrane marker. Although the physiological role of 5′NT is still mostly obscure, decreased 5′NT activity was found to be associated with a variety of immunological disorders and lymphoproliferative diseases (1–6). 5′NT was suggested to provide a marker for B- and T-lymphocyte maturation (5,7).

Keywords

Chronic Lymphocytic Leukemia Zinc Deficiency Infectious Mononucleosis Nucleotidase Activity Zinc Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • R. B. Pilz
    • 1
  • R. C. Willis
    • 1
  • S. Wanlass
    • 1
  • J. E. Seegmiller
    • 1
  1. 1.Dept. of MedicineUniversity of California San DiegoLa JollaUSA

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