Advertisement

Absence of Lymphocyte Ecto-5′-Nucleotidase in Infants with Reticuloendotheliosis and Immunodeficiency

  • E. W. Gelfand
  • C. P. Rao
  • D. McCurdy
  • N. H. Sigal
  • A. Cohen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

The association of adenosine deaminase (ADA) and purine nucleoside Phosphorylase (PNP) deficiency with life-threatening immunodeficiency has revealed the important role of purine metabolism in lymphocyte maturation and differentiation. Activities of several purine salvage enzymes, including the ecto-5′-nucleotidase (5′-NT), vary during normal T-cell maturation: immature T-cells express very low activities whereas the more mature T-cells and B cells have much higher levels.1,2

Keywords

Adenosine Deaminase Infectious Mononucleosis Purine Metabolism Purine Nucleoside Phosphorylase Nucleotidase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    N.L. Edwards, E.W. Gelfand, L. Burk, H.M. Dosch and I.H. Fox, Distribution of 5′-nucleotidase in human lymphoid tissues, Proc. Nat. Acad. Sci. 76: 3474 (1979).PubMedCrossRefGoogle Scholar
  2. 2.
    A. Cohen, H.M. Dosch and E.W. Gelfand, Induction of ecto-5′-nucleotidase activity in human thymocytes, Clin. Immunol. Immunopath. 18: 287 (1981).CrossRefGoogle Scholar
  3. 3.
    M. Rowe, G.C. DeGast, T.A.E. Platts-Mills, G.L. Asherson, A.D.B. Webster, and S.M. Johnson, Lymphocyte 5′-nucleoti-dase in primary hypogammaglobulinemia and cord blood, Clin. Exp. Immunol. 39: 337 (1980).PubMedGoogle Scholar
  4. 4.
    G.H. Reaman, N. Levin, A. Muchmore, B.J. Holiman and D.G. Poplack, Diminished lymphoblast 5′-nucleotidase activity in acute lymphoblastic leukemia with T-cell characteristics, New Eng. J. Med. 300: 1374 (1979).PubMedCrossRefGoogle Scholar
  5. 5.
    F. Quagliata, D. Faig and M. Conklyn, Studies on the lymphocyte 5′-nucleotidase in chronic lymphocytic leukemia, infectious mononucleosis, normal subpopulations, and phytohemagglutinin-stimulated cells, Cancer Res. 34: 3197 (1974).PubMedGoogle Scholar
  6. 6.
    N.L. Edwards, D.B. Magilavy, J.T. Cassidy, and I.H. Fox, Lymphocyte ecto-5′-nucleotidase deficiency in agammaglobulinemia, Science 201: 628 (1978).PubMedCrossRefGoogle Scholar
  7. 7.
    A. Cohen, A. Mansour, H.M. Dosch and E.W. Gelfand, Absence of lymphocyte ecto-5′-nucleotidase in familial reticuloen-dotheliosis and combined immunodeficiency, Clin. Immunol. Immunopath. 15: 245 (1980).CrossRefGoogle Scholar
  8. 8.
    D.A. Carson, J. Kaye, and D.B. Wasson, The potential importance of soluble deoxynucleotidase activity in mediating deoxyadenosine toxicity in human lymphoblasts, J. Immunol. 126: 348 (1981).PubMedGoogle Scholar
  9. 9.
    G.S. Omenn, Familial reticuloendotheliosis with eosinophilia, New Eng. J. Med. 273: 427 (1965).PubMedCrossRefGoogle Scholar
  10. 10.
    R.F. Barth, G.G. Vegara, S.K. Khurana, J.T. Lawman and J.B. Beckwith, Rapidly fatal familial histiocytosis associated with eosinophilia and primary immunological deficiency, Lancet 2: 503 (1972).PubMedCrossRefGoogle Scholar
  11. 11.
    S.D. Cederbaum, G. Niwayama, E.R. Stiehm, R.L. Neerhout, A.J. Ammann, W. Berman, Combined immunodeficiency presenting as the Letterer-Siwe syndrome, J. Pediat. 85: 466 (1974).PubMedCrossRefGoogle Scholar
  12. 12.
    H.D. Ochs, S.D. Davis, E. Mickelson, K.G. Lerner and R.J. Wedgwood, Combined immunodeficiency and reticuloendothe-liosis with eosinophilia, J. Pediat. 85: 463 (1974).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • E. W. Gelfand
    • 1
  • C. P. Rao
    • 1
  • D. McCurdy
    • 1
  • N. H. Sigal
    • 1
  • A. Cohen
    • 1
  1. 1.Division of Immunology Research InstituteThe Hospital for Sick ChildrenTorontoCanada

Personalised recommendations