Concentration of Nucleotides in Peripheral Blood Lymphocytes of Various Mammalian Species

  • R. A. De Abreu
  • G. J. Peters
  • J. H. Veerkamp
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


Assay of intracellular pools of nucleotides forms an important tool in the study of regulation of cellular metabolism. Concentrations of ribonucleotides are changed in blood cells of leukemic patients (1) and in those of patients with adenosine deaminase (ADA) or purine nucleoside Phosphorylase (PNP) deficiency (2–5). Treatment with deoxycoformycin results in marked changes of adenine nucleotide concentrations (6–8).


High Performance Liquid Chromatography Adenosine Deaminase Purine Nucleoside Phosphorylase Pyrimidine Nucleotide Pyrimidine Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    R.A. De Abreu, J.M. van Baal, J.A.J.M. Bakkeren, C.H.M.M. de Bruyn and E.D.A.M. Schretlen, J. of Chromatogr., 221: 45 (1982).Google Scholar
  2. 2.
    J. Donofrio, M.S. Coleman, J.J. Hutton, A. Daoud, B. Lampkin and J. Dyminski, J.Clin.Invest., 62: 884 (1978).PubMedCrossRefGoogle Scholar
  3. 3.
    D.A. Carson, J. Kay and D.B. Wasson, J.Immunol., 124: 8 (1980)PubMedGoogle Scholar
  4. 4.
    D. Hunting and J.F. Henderson, Can.J.Biochem., 59: 830 (1981)PubMedCrossRefGoogle Scholar
  5. 5.
    J.J. Hutton, D.A. Wiginton, M.S. Coleman, S.A. Fuller, S. Limouze and B.C. Lampkin, J.Clin.Invest., 68: 413 (1981)PubMedCrossRefGoogle Scholar
  6. 6.
    A.S. Bagnara and M.S. Hershfield, Proc.Natl.Acad.Sci. USA, 79: 2673 (1982).PubMedCrossRefGoogle Scholar
  7. 7.
    M.F.E. Siaw, B.S. Mitchell, C.A. Koller, M.S. Coleman and J.J. Hutton, Proc.Natl.Acad.Sci. USA, 77: 6157 (1980).PubMedCrossRefGoogle Scholar
  8. 8.
    C.M. Smith and J.F. Henderson, Biochem.Pharmacol., 31: 1545 (1982).PubMedCrossRefGoogle Scholar
  9. 9.
    G.J Peters, A. Oosterhof and J.H. Veerkamp, Int.J.Biochem. 13: 445 (1981).PubMedCrossRefGoogle Scholar
  10. 10.
    G.J Peters, A. Oosterhof and J.H. Veerkamp, These Proceedings.Google Scholar
  11. 11.
    A. Boyum, Scand.J.Clin.Lab.Invest., 21 (suppl. 97): 77 (1968).Google Scholar
  12. 12.
    S. Skupp, G. Vugrek and J.H. Ayvazian, Biochem. Pharmacol., 28: 3323 (1979).PubMedCrossRefGoogle Scholar
  13. 13.
    F.C. Schmallstieg, J.A. Nelson, G.C. Mills, T.M. Monahan, A.S. Goldman and R.M. Goldblum, J. Pediat., 91: 48 (1977).CrossRefGoogle Scholar
  14. 14.
    N.S. Magnuson, L.A. McConnell and L.E. Perryman, Comp.Biochem. Physiol., 70B: 279 (1981).Google Scholar
  15. 15.
    W.J.M. Tax, G.J. Peters and J.H. Veerkamp, Int.J.Biochem., 10: 7 (1979).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • R. A. De Abreu
    • 1
  • G. J. Peters
    • 2
  • J. H. Veerkamp
    • 2
  1. 1.Department of PediatricsCenter of Pediatric OncologyThe Netherlands
  2. 2.Center of Pediatric Oncology, Department of BiochemistrySt. Radboud Hospital Catholic University of NijmegenThe Netherlands

Personalised recommendations