Purine Interconversion Pathways in T, B, Tγ and T-Tγ Cells from Human Peripheral Blood

  • J. P. R. M. van Laarhoven
  • G. Th. Spierenburg
  • H. Collet
  • G. Delespesse
  • C. H. M. M. De Bruyn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


In the last decade it has become clear, that a number of immunological diseases are related to imbalances of purine metabolism in lymphocyte subpopulations(1,2,3). Information regarding the enzymatic make-up and metabolic characteristics of lymphocyte subpopulations, both in healthy individuals and in patients, might contribute to a better diagnosis of immunological diseases and be of importance for the development of immuno-regulatory drugs. Not only T and B cell sub-populations, but also T and B cell subsets should be included in such studies.


Peripheral Blood Mononuclear Cell Lymphocyte Subpopulation Purine Nucleoside Phosphorylase Lymphocyte Preparation Preparation Peripheral Blood Mononuclear Cell 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • J. P. R. M. van Laarhoven
    • 1
  • G. Th. Spierenburg
    • 1
  • H. Collet
    • 2
  • G. Delespesse
    • 3
  • C. H. M. M. De Bruyn
    • 1
  1. 1.Dept. of Human Genetics, Faculty of MedicineUniversity of NijmegenNijmegenThe Netherlands
  2. 2.Dept. of Immunology and BloodtransfusionHôpital St. Pierre, Free University of BrusselsBrusselsBelgium
  3. 3.Dept. of Immunology, Faculty of MedicineUniversity of MannitobaWinnipegCanada

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