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Purine Interconversion Pathways in T, B, Tγ and T-Tγ Cells from Human Peripheral Blood

  • J. P. R. M. van Laarhoven
  • G. Th. Spierenburg
  • H. Collet
  • G. Delespesse
  • C. H. M. M. De Bruyn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

In the last decade it has become clear, that a number of immunological diseases are related to imbalances of purine metabolism in lymphocyte subpopulations(1,2,3). Information regarding the enzymatic make-up and metabolic characteristics of lymphocyte subpopulations, both in healthy individuals and in patients, might contribute to a better diagnosis of immunological diseases and be of importance for the development of immuno-regulatory drugs. Not only T and B cell sub-populations, but also T and B cell subsets should be included in such studies.

Keywords

Peripheral Blood Mononuclear Cell Lymphocyte Subpopulation Purine Nucleoside Phosphorylase Lymphocyte Preparation Preparation Peripheral Blood Mononuclear Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    E.R. Giblett, J.E. Anderson, F. Cohen, B. Pollara and H.J. Meuwissen, Lancet, ii:1067 (1972).CrossRefGoogle Scholar
  2. 2.
    A.D.B. Webster, M. North, J. Allsop, G.L. Asherson and R.W.E. Watts, Clin. Exp. Immunol., 31: 456 (1978).PubMedGoogle Scholar
  3. 3.
    D.J. Levinson, D. Chalker and W.J. Arnold, J. Lab. Clin. Med., 96: 562 (1980).PubMedGoogle Scholar
  4. 4.
    R. Tung, R. Silber, F. Quagliata, M. Conklyn, J. Gottesman and R. Hirschhorn, J. Clin. Invest., 57: 756 (1976).PubMedCrossRefGoogle Scholar
  5. 5.
    A.T. Huang, G.T. Logue and H.L. Engelbrecht, Brit. J. Haematol., 34: 631 (1976).CrossRefGoogle Scholar
  6. 6.
    M. Rowe, G.C. de Gast, T.A.E. Platts-Mills, G.L. Asherson, A.D.B. Webster and S.M. Johnson, Clin. Exp. Immunol., 36: 97 (1979).PubMedGoogle Scholar
  7. 7.
    J.P.R.M. van Laarhoven, G.Th. Spierenburg, C.H.M.M. de Bruyn and E.D.A.M. Schretlen, Adv. Exp. Med. Biol., 122B:283 (1980).CrossRefGoogle Scholar
  8. 8.
    M.E. North, C.A. Newton and A.D.B. Webster, Clin. Exp. Immunol., 42: 523 (1980).PubMedGoogle Scholar
  9. 9.
    J.P.R.M. van Laarhoven, G.Th. Spierenburg and C.H.M.M. de Bruyn, J. Immunol. Methods, 39: 47 (1980).PubMedCrossRefGoogle Scholar
  10. 10.
    A. Bøyum, Scand. J. Immunol., 5, suppl. 5: 9 (1976).PubMedCrossRefGoogle Scholar
  11. 11.
    A. Saxon, J.L. Feldhaus and R.A. Robbins, J. Immunol. Methods, 12: 285 (1976).PubMedCrossRefGoogle Scholar
  12. 12.
    L. Moretta, M.C. Mingary and A. Moretta, Immunol. Rev., 45: 169 (1976).Google Scholar
  13. 13.
    J.L. Preud’homme and G. Flandrin, J. Immunol., 113: 1650 (1974).Google Scholar
  14. 14.
    N.L. Edwards, D. Magilavy, J.T. Cassidy and I.H. Fox, Science, 201: 628 (1978).PubMedCrossRefGoogle Scholar
  15. 15.
    A.R. Leech and E.W. Newsholme, Anal. Biochem., 90: 576 (1980).CrossRefGoogle Scholar
  16. 16.
    A.A. Dietz and V. Czebotar, Cancer Res., 37: 419 (1977).PubMedGoogle Scholar
  17. 17.
    P. Nygaard and J. Mejer, Adv. Exp. Med. Biol., 122B:339 (1980).CrossRefGoogle Scholar
  18. 18.
    N.L. Edwards, E.W. Gelfand, L. Burk, H.M. Dosch and I.H. Fox, Proc. Natl. Acad. Sci. U.S.A., 76: 3474 (1979).PubMedCrossRefGoogle Scholar
  19. 19.
    L.F. Thompson, G.R. Boss, H.L. Spiegelberg, T.C. Jansen, R.D. O’Connor, T.A. Waldmann, R.N. Hamburger and J.E. Seegmiller, J. Immunol., 123: 2475 (1979).PubMedGoogle Scholar
  20. 20.
    B.E. de Pauw, J.M.C. Wessels, E.J.M. Geestman, J.B.J.M. Smeulders, D.J.Th. Wagener and C. Haanen, J. Immunol. Methods, 25: 291 (1979).PubMedCrossRefGoogle Scholar
  21. 21.
    J.P.R.M. van Laarhoven, G.Th. Spierenburg, J.A.J.M. Bakkeren, E.D.A.M. Schretlen, S.J. Geerts and C.H.M.M. de Bruyn, in: “Progress in Clinical Enzymology”, Vol. 2, M. Werner and D. Goldberg, Eds., Masson Publishing Company, in press.Google Scholar
  22. 22.
    J.P.R.M. van Laarhoven, C.H.M.M. de Bruyn, H. Collet and G. Delespesse, this volume.Google Scholar
  23. 23.
    S. Gupta and R.A. Good, Clin. Exp. Immunol. 30: 222 (1977).PubMedGoogle Scholar
  24. 24.
    J.E. Seegmiller, H. Bluestein, L. Thompson, R. Willis, S. Matsumoto and D.A. Carson, in:“Models for the Study of Inborn Errors of Metabolism”, F.A. Hommes, Ed., Elsevier/North-Holland Biomedical Press, Amsterdam, p.153 (1979).Google Scholar
  25. 25.
    S. Gupta and R.A. Good, Semin. Hematol. 17: 1 (1980).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • J. P. R. M. van Laarhoven
    • 1
  • G. Th. Spierenburg
    • 1
  • H. Collet
    • 2
  • G. Delespesse
    • 3
  • C. H. M. M. De Bruyn
    • 1
  1. 1.Dept. of Human Genetics, Faculty of MedicineUniversity of NijmegenNijmegenThe Netherlands
  2. 2.Dept. of Immunology and BloodtransfusionHôpital St. Pierre, Free University of BrusselsBrusselsBelgium
  3. 3.Dept. of Immunology, Faculty of MedicineUniversity of MannitobaWinnipegCanada

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