Purine Metabolism in Human Thymocyte Subsets: Relevance for Lymphocytic Differentiation
The maturation pathway of the T lymphoid system, from (T) lymphopoietic precursor cell in the bone marrow via immature T lymphocytes in the thymus to mature immunocompetent T cells in peripheral organs and blood, is nowadays well established. Stages in T cell differentiation can be distinguished both by expression of cell surface and cytoplasmic differentiation markers (e.g., cell surface phenotyping with monoclonal antibodies to T lymphocyte (sub)populations1) and by functional capacity (e.g. differential responsiveness to mitogens like phytohaemagglutinin (PHA))2.
KeywordsAdenosine Deaminase Purine Metabolism Purine Nucleoside Phosphorylase Centrifugal Elutriation Adenosine Deaminase Deficiency
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- 10.H.J. Schuurman, J.P.A.M. Klerx, E. van den Brink, C.G. Figdor, and L. Kater, Lymphocyte differentiation in the human thymus; characteristics and function of human thymocyte subpopulations, Human Lymphocyte Differentiation, 1: 263 (1981).Google Scholar