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Purine Metabolism in Human Thymocyte Subsets: Relevance for Lymphocytic Differentiation

  • H. J. Schuurman
  • J. P. R. M. van Laarhoven
  • R. Broekhuizen
  • P. Brekelmans
  • G. Th. Spierenburg
  • C. G. Figdor
  • C. H. M. M. De Bruyn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

The maturation pathway of the T lymphoid system, from (T) lymphopoietic precursor cell in the bone marrow via immature T lymphocytes in the thymus to mature immunocompetent T cells in peripheral organs and blood, is nowadays well established. Stages in T cell differentiation can be distinguished both by expression of cell surface and cytoplasmic differentiation markers (e.g., cell surface phenotyping with monoclonal antibodies to T lymphocyte (sub)populations1) and by functional capacity (e.g. differential responsiveness to mitogens like phytohaemagglutinin (PHA))2.

Keywords

Adenosine Deaminase Purine Metabolism Purine Nucleoside Phosphorylase Centrifugal Elutriation Adenosine Deaminase Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • H. J. Schuurman
    • 1
  • J. P. R. M. van Laarhoven
    • 2
  • R. Broekhuizen
    • 1
  • P. Brekelmans
    • 1
  • G. Th. Spierenburg
    • 2
  • C. G. Figdor
    • 3
  • C. H. M. M. De Bruyn
    • 2
  1. 1.Division of ImmunopathologyUniversity HospitalUtrechtThe Netherlands
  2. 2.Dept. of Human Genetics, Faculty of MedicineUniversity of NijmegenThe Netherlands
  3. 3.Dept. of Biophysics and ImmunologyThe Netherlands Cancer InstituteAmsterdamThe Netherlands

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