Phosphorylation of Deoxyguanosine in Rat Liver Mitochondria

  • Roger A. Lewis
  • Linda F. Watkins
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


Recent studies document that mitochondria from mouse skin (1), human lung fibroblasts (2) and calf thymus (3) contain a deoxyguanosine (dG) kinase which is distinctly different from that found in the cytosol. A preliminary report (4) has shown that dG is taken up by intact, respiring rat liver mitochondria by a carrier mediated process. This report extends that study and shows that after being transported into the mitochondria, dG is phos-phorylated to its corresponding deoxynucleotide products.


Mouse Skin Mediate Process Human Lung Fibroblast Carrier Mediate Process Respire Mitochondrion 
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  1. 1.
    J. Barker and R. A, Lewis, Deoxyguanosine Kinase of Neonatal Mouse Skin Tissue, Biochim. Biophys. Acta 658: 111 (1981).PubMedCrossRefGoogle Scholar
  2. 2.
    R. A. Lewis and S. St. Jeor, Cytomegalovirus Enhanced Deoxy-guanosine Kinase Activity, Biochem. Soc. Trans. 9: 159P (1981).Google Scholar
  3. 3.
    W. R. Gower, Jr., M. C. Carr and D. H. Ives, Deoxyguanosine Kinase, Distinct Molecular Forms in Mitochondria and Cyto-sol, J. Biol. Chem. 254: 2180 (1979).PubMedGoogle Scholar
  4. 4.
    R. A. Lewis and L. F. Watkins, Uptake of Deoxyguanosine by Rat Liver Mitochondria, Fed. Proc. 41: 879 (1982).Google Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Roger A. Lewis
    • 1
  • Linda F. Watkins
    • 1
  1. 1.Department of BiochemistryUniversity of Nevada, RenoRenoUSA

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