Phosphorylation of Deoxyguanosine in Rat Liver Mitochondria
Recent studies document that mitochondria from mouse skin (1), human lung fibroblasts (2) and calf thymus (3) contain a deoxyguanosine (dG) kinase which is distinctly different from that found in the cytosol. A preliminary report (4) has shown that dG is taken up by intact, respiring rat liver mitochondria by a carrier mediated process. This report extends that study and shows that after being transported into the mitochondria, dG is phos-phorylated to its corresponding deoxynucleotide products.
KeywordsMouse Skin Mediate Process Human Lung Fibroblast Carrier Mediate Process Respire Mitochondrion
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